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Skin healing and scale regeneration in fed and unfed sea bream, Sparus auratus

Vieira, Florbela A.; Gregório, Sílvia F.; Ferraresso, Serena; Thorne, Michael A. S.; Costa, Rita; Milan, Massimo; Bargelloni, Luca; Clark, M. S.

Abstract Background Fish scales are an important reservoir of calcium and phosphorus and together with the skin function as an integrated barrier against environmental changes and external aggressors. Histological studies have revealed that the skin and scales regenerate rapidly in fish when they are lost or damaged. In the present manuscript the histological and molecular changes underlying skin and scale rege...


Insights into shell deposition in the Antarctic bivalve Laternula elliptica: ge...

Clark, M. S.; Thorne, Michael A. S.; Vieira, Florbela A.; Cardoso, João; Power, Deborah; Peck, Lloyd S.

Abstract Background The Antarctic clam, Laternula elliptica, is an infaunal stenothermal bivalve mollusc with a circumpolar distribution. It plays a significant role in bentho-pelagic coupling and hence has been proposed as a sentinel species for climate change monitoring. Previous studies have shown that this mollusc displays a high level of plasticity with regard to shell deposition and damage repair against ...


The serendipitous origin of chordate secretin peptide family members

Cardoso, J. C. R.; Vieira, Florbela A.; Gomes, Ana S.; Power, Deborah

Background: The secretin family is a pleotropic group of brain-gut peptides with affinity for class 2 G-protein coupled receptors (secretin family GPCRs) proposed to have emerged early in the metazoan radiation via gene or genome duplications. In human, 10 members exist and sequence and functional homologues and ligand-receptor pairs have been characterised in representatives of most vertebrate classes. Secreti...


Evolution of secretin family GPCR members in the metazoa

Cardosos, J. R. C.; Pinto, Vanda C.; Vieira, Florbela A.; Clark, Melody S.; Power, Deborah

Background: Comparative approaches using protostome and deuterostome data have greatly contributed to understanding gene function and organismal complexity. The family 2 G-protein coupled receptors (GPCRs) are one of the largest and best studied hormone and neuropeptide receptor families. They are suggested to have arisen from a single ancestral gene via duplication events. Despite the recent identification of ...


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Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia