We present here an overview of the scientific literature concerning the clinical application of autografts and allografts of the skeletal tissues and of the natural and synthetic bone graft substitutes available in small animal orthopedic surgery for resolution of congenital, traumatic and tumoral etiology situations or for reconstructive artroplastic surgeries. This article focuses the terminology, definitions...
Este trabalho procura identificar os sectores de actividade que estiveram na base do crescimento económico da região do Algarve, a região sul de Portugal continental, bem como os estímulos de crescimento que conseguiram transmitir aos sectores endógenos da região no período entre 1995 e 2003. Com a adopção do modelo de Base Económica, aos níveis inter-regional e intra-regional, os resultados sugerem que fora...
Mesenchymal stem cells have a great potential for application in cell based therapies, such as tissue engineering. Adipose derived stem cells have shown the capacity to differentiate into several lineages, and have been isolated in many animal species. Dog is a very relevant animal model to study several human diseases and simultaneously an important subject in veterinary medicine. Thus, in this study we asses...
Relatório apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do título de pós-doutoramento em Psicologia da Aprendizagem e do Ensino
Periodontal disease (PD) is an inflammatory pathology highly prevalent both in humans and in dogs, which is characterized by destruction of the periodontal ligament, cementum and alveolar bone. The development of new therapies, such as Tissue Engineering strategies, is mandatory due to the inefficacy of conventional therapies currently used. Dog is a very relevant animal model to study several human diseases, s...
Bone extracellular matrix (ECM) is composed of mineralized collagen fibrils which support biological apatite nucleation that participates in bone outstanding properties. Understanding and mimicking bone morphological and physiological parameters at a biological scale is a major challenge in tissue engineering scaffolding. Using emergent (nano)technologies scaffold designing may be critically improved, enabling ...
This study aims to assess the in vivo performance of cell–scaffold constructs composed of goat marrow stromal cells (GBMCs) and SPCL (a blend of starch with polycaprolactone) fibre mesh scaffolds at different stages of development, using an autologous model. GBMCs from iliac crests were seeded onto SPCL scaffolds and in vitro cultured for 1 and 7 days in osteogenic medium. After 1 and 7 days, the constructs wer...
Values of serum tartrate-resistant acid phosphatase (TRAP)activity were obtained in adult dogs and its biological variability was assessed. Nine healthy skeletally mature Portuguese Podengo dogs were used for the determination of TRAP, total and bone alkaline phosphatase serum activities, and also to styudy their relashionship with serum minerals, namely calcium (Ca) phosphorous (P),and magnesium (Mg).The serum...
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