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Design and characterization of a biodegradable double-layer scaffold aimed at p...
Requicha, J. F.; Viegas, C. A. A.; Hede, Shantesh; Leonor, I. B.; Reis, R. L.; Gomes, Manuela E.The inefficacy of the currently used therapies in achieving the regeneration ad integrum of the periodontium stimulates the search for alternative approaches, such as tissue-engineering strategies. Therefore, the core objective of this study was to develop a biodegradable double-layer scaffold for periodontal tissue engineering. The design philosophy was based on a double-layered construct obtained from a blend...
Biological evaluation of intervertebral disc cells in different formulations of...
Khang, G.; Lee, S. K.; Kim, H. N.; Silva-Correia, J.; Gomes, Manuela E.; Viegas, C. A. A.; Dias, Isabel R.; Oliveira, Joaquim M.; Reis, R. L.Gellan gum (GG)-based hydrogels are advantageous in tissue engineering not only due to their ability to retain large quantities of water and provide a similar environment to that of natural extracellular matrix (ECM), but also because they can gelify in situ in seconds. Their mechanical properties can be fine-tuned to mimic natural tissues such as the nucleus pulposus (NP). This study produced different formula...
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