Encontrados 6 documentos, a visualizar página 1 de 1
Sialyl Tn-Expressing Bladder Cancer Cells Induce a Tolerogenic Phenotype in Inn...
Carrascal, M; Severino, P; Cabral, MG; Silva, M; Ferreira, JA; Calais da Silva, F; Quinto, H; Pen, C; Ligeiro, D; Lara Santos, L; Dall'Olio, FDespite the wide acceptance that glycans are centrally implicated in immunity, exactly how they contribute to the tilt immune response remains poorly defined. In this study, we sought to evaluate the impact of the malignant phenotype-associated glycan, sialyl-Tn (STn) in the function of the key orchestrators of the immune response, the dendritic cells (DCs). In high grade bladder cancer tissue, the STn antigen ...
A brief overview of the evolution and main features of the biotechnology industry
Fontes, M.; Videira, P.This paper offers an overview of the origin, evolution and main features of the biotechnology industry, putting particular emphasis on the behaviour of one key actor – the dedicated biotechnology firm. It starts with a brief historical background detailing the origin and dynamics of the industry, which is followed by a more detailed examination of the firms’ strategies, business models and networking behaviour....
The emergence of a knowledge-intensive sector in Portugal: social networks and ...
Salavisa, I.; Videira, P.; Sousa, C.This paper deals with the development of the software for telecommunications sector, a relatively small segment in the global software industry though one of its most innovative. In fact, its products address the demand of one of the most sophisticated and fastest changing industries today, the telecommunications industry. We attempt to explain how and why this sector has evolved in Portugal since its inception...
Building a bridge: social networks and technological regimes in biotechnology a...
Salavisa, I.; Fontes, M.; Sousa, C.; Videira, P.The paper investigates the influence of technological regimes on the composition and structure of firms’ knowledge networks. We combine insights from two hitherto unconnected bodies of research: one relating technological regimes with the nature of knowledge; and the other relating knowledge and types of innovation with network configuration. Drawing on this framework, we build a number of propositions on the ...
Knowledge access and location decisions in biotechnology: the spatial dimension...
Fontes, M.; Sousa, C.; Videira, P.DINÂMIA'CET, Dezembro de 2009. ; This paper addresses the spatial dimension of knowledge sourcing strategies, investigating the role played by social networks on the access to scientific and technological knowledge by new biotechnology firms. Our approach takes into consideration the impact of various forms of proximity - geographical, social, cognitive and organisational - on the development of key relationsh...
Entrepreneurship and social networks in IT sectors: the case of the software in...
Salavisa, I.; Videira, P.; Santos, F.DINÂMIA, Dezembro de 2008. ; Empirical research has repeatedly confirmed that social networks are important for the creation, survival and growth of new companies. In this article, the leading research questions are: 1) how do networks contribute to the creation of software firms and further development of a competitive IT sector; 2) what is the structure and features of those networks; 3) how have they evolve...
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