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Synthesis and studies of calcium channel blocking and antioxidant activities of...
Rucins, Martins; Kaldre, Dainis; Pajuste, Karlis; Fernandes, Maria A. S.; Vicente, Joaquim A. F.; Klimaviciusa, Linda; Jaschenko, ElinaThe novel 1,4-dihydropyridine derivatives containing the cationic pyridine moiety at the position 4, and the N-propargyl group as a substituent at position 1 of the 1,4-DHP cycle were designed, synthesised, and assessed in biological tests. Among all the novel compounds, the 4-(N-dodecyl) pyridinium group-containing compounds 11 (without the N-propargyl group) and 12 (with the N-propargyl group) demonstrated th...
Ecophysiological tolerance of duckweeds exposed to copper
Kanoun-Boulé, Myriam; Vicente, Joaquim A. F.; Nabais, Cristina; Prasad, M. N. V.; Freitas, Helenahttp://www.sciencedirect.com/science/article/B6T4G-4TGXP9V-1/2/0652ab94eb95eab94ea56a82c424997b
Comparative effects of three 1,4-dihydropyridine derivatives [OSI-1210, OSI-121...
Fernandes, Maria A. S.; Pereira, Susana P. S.; Jurado, Amália S.; Custódio, José B. A.; Santos, Maria S.; Moreno, António J. M.; Duburs, GunarsThe 1,4-dihydropyridines OSI-1210, OSI-1211 (etaftoron), and OSI-3802 are compounds with similar chemical structure. They differ by the length of the alkoxyl chain in positions 3 and 5 of the dihydropyridine (DHP) ring and by their pharmacological action characteristics. However, as far as we know, a clear relationship between the effects of these compounds and the length of the alkoxyl chain in positions 3 and...
Tetrandrine concentrations not affecting oxidative phosphorylation protect rat ...
Fernandes, Maria A. S.; Custódio, José B. A.; Santos, Maria S.; Moreno, António J. M.; Vicente, Joaquim A. F.The effects of tetrandrine (6,6', 7,12-tetramethoxy-2, 2'-dimethyl-berbaman) on the mitochondrial function were assessed on oxidative stress, mitochondrial permeability transition (MPT), and bioenergetics of rat liver mitochondria. At concentrations lower than 100 nmol/mg protein, tetrandrine decreased the hydrogen peroxide formation, the extent of lipid peroxidation, the susceptibility to Ca2+-induced opening ...
Teaching about citric acid cycle using plant mitochondrial preparations: Some a...
Vicente, Joaquim A. F.; Gomes-Santos, Carina S. S.; Sousa, Ana Paula M.; Madeira, Vítor M. C.Potato tubers and turnip roots were used to prepare purified mitochondria for laboratory practical work in the teaching of the citric acid cycle (TCA cycle). Plant mitochondria are particularly advantageous over the animal fractions to demonstrate the TCA cycle enzymatic steps, by using simple techniques to measure O2 consumption and transmembrane potential (ΔΨ). The several TCA cycle intermediates induce speci...
Regulation by Magnesium of Potato Tuber Mitochondrial Respiratory Activities
Vicente, Joaquim A. F.; Madeira, Vítor M. C.; Vercesi, Anibal E.Dehydrogenase activities of potato tuber mitochondria and corresponding phosphorylation rates were measured for the dependence on external and mitochondrial matrix Mg2+. Magnesium stimulated state 3 and state 4 respiration, with significantly different concentrations of matrix Mg2+ required for optimal activities of the several substrates. Maximal stimulation of respiration with all substrates was obtained at 2...
Glibenclamide interferes with mitochondrial bioenergetics by inducing changes o...
Fernandes, Maria A. S.; Santos, Maria S.; Moreno, António J. M.; Duburs, Gunars; Oliveira, Catarina R.; Vicente, Joaquim A. F.The interference of glibenclamide, an antidiabetic sulfonylurea, with mitochondrial bioenergetics was assessed on mitochondrial ion fluxes (H+, K+, and Cl-) by passive osmotic swelling of rat liver mitochondria in K-acetate, KNO3, and KCl media, by O2 consumption, and by mitochondrial transmembrane potential (Deltapsi). Glibenclamide did not permeabilize the inner mitochondrial membrane to H+, but induced perme...
Effects of 1,4-dihydropyridine derivatives (cerebrocrast, gammapyrone, glutapyr...
Fernandes, Maria A. S.; Santos, Maria S.; Vicente, Joaquim A. F.; Moreno, António J. M.; Velena, Astrida; Duburs, Gunars; Oliveira, Catarina R.The potential protective action of 1,4-dihydropyridine derivatives (cerebrocrast, gammapyrone, glutapyrone, and diethone) against oxidative stress was assessed on mitochondrial bioenergetics, inner membrane anion channel (IMAC), Ca2+-induced opening of the permeability transition pore (PTP), and oxidative damage induced by the oxidant pair adenosine diphosphate (ADP)/Fe2+ (lipid peroxidation) of mitochondria is...
Comparative effects of herbicide dicamba and related compound on plant mitochon...
Peixoto, Francisco; Vicente, Joaquim A. F.; Madeira, Vítor M. C.The herbicide dicamba (3,6-dichloro-2-methoxybenzoic acid) was evaluated for its effects on bioenergetic activities of potato tuber mitochondria to elucidate putative mechanisms of action and to compare its toxicity with 2-chlorobenzoic acid. Dicamba (4 mumol/mg mitochondrial protein) induces a limited stimulation of state 4 respiration of ca. 10%, and the above concentrations significantly inhibit respiration,...
Differential sensitivities of plant and animal mitochondria to the herbicide pa...
Vicente, Joaquim A. F.; Peixoto, Francisco; Lopes, M. Ludovina; Madeira, Vítor M. C.Paraquat herbicide is toxic to animals, including humans, via putative toxicity mechanisms associated to microsomal and mitochondrial redox systems. It is also believed to act in plants by generating highly reactive oxygen free radicals from electrons of photosystem I on exposure to light. Paraquat also acts on non-chlorophyllous plant tissues, where mitochondria are candidate targets, as in animal tissues. The...
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