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Reversibility of prion misfolding by constant-pH molecular dynamics simulations

Tese de mestrado, Bioquímica, Universidade de Lisboa, Faculdade de Ciências, 2010 ; The prion protein (PrP) is the cause of a group of diseases known as Transmissible Spongiform Encephalopathies (TSEs). Creutzfeldt-Jakob and Bovine Spongiform Encephalopathy are examples of TSEs. The normal form of PrP (PrPC) is monomeric and soluble, however, it can misfold into a pathogenic form (PrPSc). This last form has a ...