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Inflammatory events in hippocampal slice cultures prime neuronal susceptibility...
Bernardino, Liliana; Balosso, Silvia; Ravizza, Teresa; Marchi, Nicola; Ku, George; Randle, John C.; Malva, João O.; Vezzani, AnnamariaWe investigated the consequences of transient application of specific stimuli mimicking inflammation to hippocampal tissue on microglia activation and neuronal cell vulnerability to a subsequent excitotoxic insult. Two-week-old organotypic hippocampal slice cultures, from 7-day-old C57BL/6 donor mice, were exposed for 3 h to lipopolysaccharide (LPS; 10 ng/mL) followed by 3 h co-incubation with 1 mM ATP, or 100 ...
Inactivation of Caspase-1 in Rodent Brain: A Novel Anticonvulsive Strategy
Ravizza, Teresa; Lucas, Sian-Marie; Balosso, Silvia; Bernardino, Liliana; Ku, George; Noé, Francesco; Malva, João; Randle, John C. R.; Allan, StuartPurpose: Cytokines and related inflammatory mediators are rapidly synthesized in the brain during seizures. We previously found that intracerebral administration of interleukin-1 (IL-1)-03B2 has proconvulsant effects, whereas its endogenous receptor antagonist (IL-1Ra) mediates potent anticonvulsant actions in various models of limbic seizures. In this study, we investigated whether seizures can be effectively ...
Modulator effects of interleukin-1beta and tumor necrosis factor-alpha on AMPA-...
Bernardino, Liliana; Xapelli, Sara; Silva, Ana P.; Jakobsen, Birthe; Poulsen, Frantz R.; Oliveira, Catarina R.; Vezzani, Annamaria; Malva, João O.The inflammatory cytokines interleukin-1\u2424 and tumor necrosis factor-\u2423 (TNF-\u2423) have been identified as mediators of several forms of neurodegeneration in the brain. However, they can produce either deleterious or beneficial effects on neuronal function. We investigated the effects of these cytokines on neuronal death caused by exposure of mouse organotypic hippocampal slice cultures to toxic conce...
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