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Uso de ingredientes provenientes de OGM em rações e seu impacto na produção de ...
Vercesi,Anibal E.; Ravagnani,Felipe G.; Di Ciero,LucianaDesde os primórdios o homem buscou selecionar as plantas alimentícias para maior produtividade. O conhecimento da estrutura do DNA permitiu que a engenharia genética se desenvolvesse consideravelmente fornecendo ferramentas para a realização de alterações específicas no genoma. Os produtos destas alterações são denominados transgênicos ou organismos geneticamente modificados (OGM) e apresentam alto potencial de...
High susceptibility of activated lymphocytes to oxidative stress-induced cell d...
Degasperi,Giovanna R.; Castilho,Roger F.; Vercesi,Anibal E.The present study provides evidence that activated spleen lymphocytes from Walker 256 tumor bearing rats are more susceptible than controls to tert-butyl hydroperoxide (t-BOOH)-induced necrotic cell death in vitro. The iron chelator and antioxidant deferoxamine, the intracellular Ca2+ chelator BAPTA, the L-type Ca2+ channel antagonist nifedipine or the mitochondrial permeability transition inhibitor cyclosporin...
Mitochondrial DNA damage associated with lipid peroxidation of the mitochondria...
Almeida,Andréa M.; Bertoncini,Clélia R.A.; Borecký,Jiri; Souza-Pinto,Nadja C.; Vercesi,Aníbal E.Iron imbalance/accumulation has been implicated in oxidative injury associated with many degenerative diseases such as hereditary hemochromatosis, beta-thalassemia, and Friedreich's ataxia. Mitochondria are particularly sensitive to iron-induced oxidative stress - high loads of iron cause extensive lipid peroxidation and membrane permeabilization in isolated mitochondria. Here we detected and characterized mito...
Regulation by Magnesium of Potato Tuber Mitochondrial Respiratory Activities
Vicente, Joaquim A. F.; Madeira, Vítor M. C.; Vercesi, Anibal E.Dehydrogenase activities of potato tuber mitochondria and corresponding phosphorylation rates were measured for the dependence on external and mitochondrial matrix Mg2+. Magnesium stimulated state 3 and state 4 respiration, with significantly different concentrations of matrix Mg2+ required for optimal activities of the several substrates. Maximal stimulation of respiration with all substrates was obtained at 2...
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