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Clinical and genetic factors predicting response to therapy in patients with Cr...
Cravo, Marília; Ferreira, Paula; Sousa, Patrícia; Moura-Santos, Paula; Velho, Sónia; Tavares, Lurdes; Deus, João Ramos; Ministro, PaulaAim - To identify clinical and/or genetic predictors of response to several therapies in Crohn’s disease (CD) patients. Methods - We included 242 patients with CD (133 females) aged (mean ± standard deviation) 39 ± 12 years and a disease duration of 12 ± 8 years. The single-nucleotide polymorphisms (SNPs) studied were ABCB1 C3435T and G2677T/A, IL23R G1142A, C2370A, and G9T, CASP9 C93T, Fas G670A and LgC844T, a...
Clinical impact of HFE Mutations in portuguese patients with Chronic Hepatitis C
Ferreira, Joana; Baldaia, Cilénia; Inácio, Ângela; Bicho, Manuel; Velosa, José; Faustino, Paula; Serejo, FátimaINTRODUCTION: Chronic hepatitis C (CHC) is often associated with alterations in iron and lipid metabolisms, which may affect the long-term prognosis and the response to antiviral treatment. Some studies suggested that the occurrence of HFE mutations may contribute to modulate these metabolisms in CHC. Here, the prevalence of two HFE mutations (C282Y and H63D) was determined in a group of Portuguese CHC patients...
Análise do sistema H2 - energia renovável para edifícios em Portugal
Velosa, José Joaquim MatosEsta dissertação tem como objectivo principal analisar o desempenho económico, energético e ambiental no uso de pilhas de combustível alimentadas a hidrogénio em substituição da electricidade fornecida pela rede eléctrica em edifícios residenciais. O hidrogénio é gerado no edifício utilizando fontes renováveis, como por exemplo, solar e eólica. Considerou-se para o estudo um edifício localizado na região de Far...
The usefulness of ultrasound in the classification of chronic liver disease
Ribeiro, Ricardo; Marinho, Rui; Velosa, José; Ramalho, Fernando; Sanches, João; Suri, J. S.Chronic Liver Disease is a progressive, most of the time asymptomatic, and potentially fatal disease. In this paper, a semi-automatic procedure to stage this disease is proposed based on ultrasound liver images, clinical and laboratorial data. In the core of the algorithm two classifiers are used: a k nearest neighbor and a Support Vector Machine, with different kernels. The classifiers were trained with the pr...
Chronic liver disease staging classification based on ultrasound, clinical and ...
Ribeiro, Ricardo; Marinho, Rui; Velosa, José; Ramalho, Fernando; Sanches, JoãoIn this work the identification and diagnosis of various stages of chronic liver disease is addressed. The classification results of a support vector machine, a decision tree and a k-nearest neighbor classifier are compared. Ultrasound image intensity and textural features are jointly used with clinical and laboratorial data in the staging process. The classifiers training is performed by using a population of ...
Diffuse liver disease classification from ultrasound surface characterization, ...
Ribeiro, Ricardo; Marinho, Rui; Velosa, José; Ramalho, Fernando; Sanches, JoãoIn this work liver contour is semi-automatically segmented and quantified in order to help the identification and diagnosis of diffuse liver disease. The features extracted from the liver contour are jointly used with clinical and laboratorial data in the staging process. The classification results of a support vector machine, a Bayesian and a k-nearest neighbor classifier are compared. A population of 88 patie...
Influence of hepatitis C virus replication on splenic lymphoma with villous lym...
Nunes, Joana; Tato Marinho, Rui; Raposo, João; Velosa, JoséThe association between hepatitis C and B-cell non-Hodgkin lymphoma (NHL) has been suggested by several studies. We report the case of a 70 year-old patient with the diagnosis of chronic hepatitis C and splenic lymphoma with villous lymphocytes, who had undergone splenectomy and chemotherapy with fludarabine, with transient effectiveness. He was sent to our Hepatology Clinic for the treatment of hepatitis C, an...
Controlo automático de um interferómetro para monitorização e caracterização de...
Velosa, José Eduardo CorreiaA indústria de sensores de fibra óptica está a tornar-se cada vez mais importante e emprega diferentes técnicas que permitem monitorizar uma grande variedade de parâmetros. Uma das técnicas que apresenta grandes potencialidades, devido ao seu elevado desempenho, é a técnica interferométrica, que fornece, simultaneamente, uma grande sensibilidade e uma larga gama dinâmica. Além destas vantagens, juntam-se as van...
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