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New insight into the discrimination between omeprazole enantiomers by cyclodext...

Figueiras, A.; Sarraguça, J. M. G.; Pais, A. A. C. C.; Veiga, J. F.; Carvalho, R. A.

We report results regarding the use of 1H-NMR spectroscopy in the study of the conformational behaviour and optical activity of omeprazole. Changes in the chemical shifts of chosen atoms reveal that the conformational behaviour of omeprazole is temperature and pH sensitive. Separation and identification of omeprazole enantiomers in the presence of natural and derivative cyclodextrins, such as ß-cyclodextrin (ßC...

Data: 2008 | Origem: Estudo Geral - Universidade de Coimbra

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Polymerase Chain Reaction Screening for Fungemia and/or Invasive Fungal Infecti...

Ribeiro, P; Costa, F; Monteiro, A; Caldas, J; Silva, M; Ferreira, G; Veiga, J; Sousa, MO; Viegas, MP; Santos, E; Gonçalves, AJ; Sousa, AB

INTRODUCTION: Invasive fungal infections (IFIs) are a life-threatening complication in patients with hematologic malignancies, mainly in acute leukemia patients, following chemotherapy. IFI incidence is increasing, and associated mortality remains high due to unreliable diagnosis. Antifungal drugs are often limited by inadequate antimicrobial spectrum and side effects. Thus, the detection of circulating fungal ...

Data: 2006 | Origem: Repositório do Centro Hospitalar de Lisboa Central, EPE

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