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Hydrophilic and hydrophobic cyclodextrins in a new sustained release oral formu...
Fernandes, Catarina Marques; Ramos, Pedro; Falcão, Amílcar Celta; Veiga, Francisco José BaptistaThe feasibility of using complexes with cyclodextrins (CDs) in nicardipine (NC) controlled delivery has been examined, with a view to extending the pharmaceutical applications spectrum of these carriers. For a fast release fraction, a hydrophilic [beta]-cyclodextrin derivative (hydroxypropyl-[beta]-cyclodextrin) was employed to form a water-soluble complex. For the sustained-releasing portion, triacetyl-[beta]-...
A simple method for nicardipine hydrochloride quantification in plasma using so...
Fernandes, Catarina Marques; Veiga, Francisco José BaptistaA simple and sensitive reversed-phase liquid chromatography method was developed and validated for the determination of nicardipine hydrochloride (NC) in rabbit plasma. Nicardipine hydrochloride and nimodipine, used as internal standard, were initially extracted from plasma by a rapid solid-phase extraction using C18 cartridges. After extraction, nicardipine hydrochloride was separated by HPLC on a C18 column a...
Hydrophilic and hydrophobic cyclodextrins in a new sustained release oral formu...
Fernandes, Catarina Marques; Ramos, Pedro; Falcão, Amílcar; Veiga, Francisco José BaptistaThe feasibility of using complexes with cyclodextrins (CDs) in nicardipine (NC) controlled delivery has been examined, with a view to extending the pharmaceutical applications spectrum of these carriers. For a fast release fraction, a hydrophilic [beta]-cyclodextrin derivative (hydroxypropyl-[beta]-cyclodextrin) was employed to form a water-soluble complex. For the sustained-releasing portion, triacetyl-[beta]-...
Effect of the hydrophobic nature of triacetyl-beta-cyclodextrin on the complexa...
Fernandes, Catarina Marques; Veiga, Francisco José BaptistaThe inclusion ability of triacetyl-beta-cyclodextrin (TAbetaCD), a hydrophobic cyclodextrin (CD) derivative was examined, using nicardipine hydrochloride (NC) as model drug. The binary compounds were prepared in a 1 : 1 molar ratio by the kneading and the spray-drying techniques. In order to confirm the complexation between NC and TAbetaCD in the solid state, differential scanning calorimetry, X-ray diffractome...
Molecular modelling and 1H-NMR: ultimate tools for the investigation of tolbuta...
Veiga, Francisco José Baptista; Fernandes, Catarina Marques; Carvalho, Rui Albuquerque; Geraldes, Carlos Frederico Gusmão CamposA structural study of the inclusion compound of tolbutamide (TBM) with beta-cyclodextrin (beta-CD) and hydroxypropyl-beta-cyclodextrin (HP-beta-CD) was attempted by means of 1H-nuclear magnetic resonance (1H-NMR) experiments and computer molecular modelling. To establish the stoichiometry and stability constant of the beta-CD:TBM complex, the continuous variation method was used. The presence of true inclusion ...
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