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The interplay between HIV-1 gp41, membranes and pre-fusion antiviral agents

Tese de doutoramento em Bioquímica (Biofísica Molecular), apresentada à Universidade de Lisboa através da Faculdade de Ciências, 2008 ; The HIV-1 envelope glycoprotein complex plays an important role in viral entry. Its surface subunit gp120 is responsible for virus binding to cellular receptors, and the transmembrane subunit gp41 mediates fusion of the virus with the target cell. Different functional regions ...