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Effect of Food on the Pharmacokinetic Profile of Etamicastat (BIA 5-453)
Vaz-da-Silva, Manuel; Nunes, Teresa; Rocha, José F.; Falcão, Amílcar; Almeida, Luis; Soares-da-Silva, PatricioBackground Etamicastat is a novel, potent, and reversible peripheral dopamine-β-hydroxylase inhibitor that has been administered orally at doses up to 600 mg once daily for 10 days to male healthy volunteers and appears to be well tolerated. Objective The aim of this study was to investigate the effect of food on the pharmacokinetics of etamicastat. Material and Methods A single-center, open-label, randomized...
Pharmacokinetic-pharmacodynamic interaction between Nebicapone and controlled-r...
Nunes, Teresa; Rocha, José F.; Fernendes-Lopes, Carlos; Costa, Raquel; Torrão, Leonel; Loureiro, Ana I.; Falcão, Amílcar; Vaz-da-Silva, ManuelBackground: Nebicapone is a reversible catechol-O-methyltransferase (COMT) inhibitor. Coadministration of a COMT inhibitor with levodopa and a dopa-decarboxylase inhibitor (carbidopa or benserazide) increases levodopa exposure and its therapeutic effect. Objectives: The primary objective of this study was to investigate the effect of nebicapone (50, 100, and 200 mg), compared with placebo, on levodopa pharmacok...
EFFECT OF ESLICARBAZEPINE ACETATE ON THE STEADYSTATE PHARMACOKINETICS OF DIGOX...
Maia, Joana; Almeida, Luís; Vaz-da-Silva, Manuel; Soares, Eva; Tavares, Susana; Falcão, Amílcar; Soares-da-Silva, PatrícioTo investigate the effect of eslicarbazepine acetate, a new voltage-gated sodium channel blocker, on the steady-state pharmacokinetics of digoxin ; AES Proceedings Annual Meeting of the American Epilepsy Society
ESLICARBAZEPINE ACETATE PHARMACOKINETICS AFTER SINGLE AND REPEATED DOSES IN HEA...
Vaz-da-Silva, Manuel; Nunes, Teresa; Soares, Eva; Rocha, José Francisco; Tavares, Susana; Falcão, Amilcar; Almeida, Luís; Soares-da-Silva, PatricioThe objective was to determine the pharmacokinetics of eslicarbazepine acetate following single and repeated doses. ; AES Proceedings Annual Meeting of the American Epilepsy Society
ESLICARBAZEPINE ACETATE PHARMACOKINETICS AFTER SINGLE AND REPEATED DOSES IN HEA...
Vaz-da-Silva, Manuel; Nunes, Teresa; Soares, Eva; Rocha, José Francisco; Tavares, Susana; Falcão, Amílcar; Almeida, Luís; Soares-da-Silva, PatricioThe objective was to determine the pharmacokinetics of eslicarbazepine acetate following single and repeated doses. ; AES Proceedings Annual Meeting of the American Epilepsy Society
Pharmacokinetic–pharmacodynamic interaction between BIA 3-202, a novel COMT inh...
Silveira, Pedro; Vaz-da-Silva, Manuel; Almeida, Luís; Maia, Joana; Falcão, Amílcar; Loureiro, Ana; Torrão, Leonel; Machado, Rita; Wright, LyndonBIA 3-202 is a novel catechol-O-methyltransferase (COMT) inhibitor being developed for use as a levodopa-sparing agent in Parkinson_s disease. This study investigated the effect of four single oral doses of BIA 3-202 (50 mg, 100 mg, 200 mg, and 400 mg) compared with placebo on plasma concentrations of levodopa and its metabolite 3-O-methyl-levodopa (3-OMD) and on inhibition of erythrocyte COMT in healthy subjec...
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