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Adaptação a situações de stress no Taekwondo : importância dos processos emocio...

Clinical manifestations of pandemic (H1N1) 2009 in the ambulatory setting

INTRODUCTION: In June 2009, the World Health Organization declared an influenza pandemic associated with the pandemic (H1N1) 2009 strain. It was summer in the northern hemisphere, and therefore travelling and vacation time, which also provided an increased opportunity for the dissemination of respiratory diseases. METHODOLOGY: We reviewed the paper case report forms from all the patients with influenza-like il...

Detection of the protease codon 35 amino acid insertion in sequences from treat...

BACKGROUND: Amino acids insertions in the protease (PR) coding region have been reported in protease inhibitors (PIs) treatment-naïve and experienced HIV-1 infected individuals ranging from 0.1% to 4.55% and have been rarely found in non-B HIV-1 subtype strains. OBJECTIVES: To investigate the presence of amino acid insertions in the PR coding region in sequences from treatment-naïve HIV-1 infected individuals ...

New developments in OCT evaluations

Diabetic macular edema (DME) is one of the most common causes for visual loss (Ciulla et al., Diabetes Care, 2003). DME is characterized by an abnormal increase of the retinal thickness (RT) due to the accumulation of liquids in the retinal tissue, consequence of the first response to the inflammatory process occurring in diabetic retinopathy (DR). It is therefore considered one of the most important indicators...

Risk markers for progression of mild nonproliferative retinopathy to clinically...

Purpose To determine risk markers for the development of clinically significant macular edema (CSME) needing photocoagulation treatment in type 2 diabetic patients with mild nonproliferative retinopathy (NPDR), during a 7-year period. Methods Fifty-one type 2 diabetic patients with mild NPDR, followed-up for 2 years as controls of diabetic retinopathy clinical trials, were selected. Patients underwent ophthalmo...

Diabetic macular edema. Clinical characterization

The most frequent cause of progressive visual loss due to diabetes is diabetic macular edema. There is retinal edema when there is any increase of water in the retinal tissue resulting in an increase in its volume, i.e., thickness. In diabetes, the inner Blood-Retinal Barrier (BRB) opens resulting in increasing movements of fluids and molecules into the retina. In a situation of open BRB there is extracellular ...

Calcium dobesilate prevents changes in tight junction proteins in the retina in...

Purpose Calcium dobesilate has been found to correct the excessive vascular permeability associated with diabetes in the retina of diabetic patients and in experimental diabetes. However, the molecular mechanisms underlying these effects are not elucidated yet. In this study, we investigated the potential protective effect of calcium dobesilate against changes in tight junction proteins (occludin, ZO-1 and clau...

Retinal thickness vs. retinal sensitivity at the central human macula

Purpose To assess the detailed correlation between retinal thickness and retinal visual function in the central 300 µm human macular area. Methods Twenty-four eyes with clinically significant macular edema (CSME) (12 eyes with and 12 eyes without central foveal involvement) underwent retinal thickness measurement (RT) and retinal sensitivity, performed by Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA, USA) and ...

Host- and microbe-related risk factors for and pathophysiology of fatal Rickett...

BACKGROUND: The pathophysiologic mechanisms that determine the severity of Mediterranean spotted fever (MSF) and the host-related and microbe-related risk factors for a fatal outcome are incompletely understood. METHODS: This prospective study used univariate and multivariate analyses to determine the risk factors for a fatal outcome for 140 patients with Rickettsia conorii infection admitted to 13 Portuguese h...

Chorioretinal anastomosis and photodynamic therapy:a two-year follow-up study

Abstract Background To evaluate the two-year efficacy of photodynamic therapy with Visudyne (PDT) in neovascular age-related macular degeneration (AMD) eyes with chorioretinal anastomosis (CRA). Methods A non-randomized, institutional, prospective study, of 28 consecutive eyes of 23 patients, with CRA, treated with PDT. Masked best corrected visual acuity (VA) and angiographic features at baseline and duri...