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Controlled delivery achieved with bi-layer matrix devices produced by co-inject...
Vaz, Cláudia M.; Doeveren, P. F. N. M. van; Dias, Gustavo R.; Reis, R. L.; Cunha, A. M.The aim of this study was to design new soy protein-based bi-layered co-injection moulded matrix systems aimed to achieve controlled drug delivery. The devices consisted of a drug-free outer layer (skin) and a drug-containing core. The systems overcame the inherent disadvantage of non-linear release associated with diffusion-controlled single-layer matrix devices by providing additional releasing area with time...
Effect of crosslinking, thermal treatment and UV irradiation on the mechanical ...
Vaz, Cláudia M.; Graaf, L. A. de; Reis, R. L.; Cunha, A. M.Gelatine (GEL), soy (SI), casein (CAS) and sodium-caseinate (NaCAS) solutions were cast to produce protein films. All the proteins were chemically modified by adding glyoxal to the film-forming solutions in amounts varying from 0 to 0.9% (w/w based on the protein content). After casting, the same films were also submitted to a heat treatment performed at 80 °C or UV irradiation. The effect of those chemical/phy...
In vitro degradation and cytocompatibility evaluation of novel soy and sodium c...
Silva, G. A.; Vaz, Cláudia M.; Coutinho, O. P.; Cunha, A. M.; Reis, R. L.Soy- and casein-based membranes are newly proposed materials disclosing a combination of properties that might allow for their use in a range of biomedical applications. Two of the most promising applications are drug delivery carrier systems and wound dressing membranes. As for all newly proposed biomaterials, a cytotoxic scanning must be performed as a preliminary step in the process of the determination of t...
Soy matrix drug delivery systems obteined by melt-processing techniques
Vaz, Cláudia M.; Doeveren, P. F. N. M. van; Reis, R. L.; Cunha, A. M.The aim of this study was to develop new soy protein drug delivery matrix systems by melt-processing techniques, namely, extrusion and injection moulding. The soy matrix systems with an encapsulated drug (theophylline, TH) were previously compounded by extrusion performed at two different pH values, (i) pH 4 (SIpDtp) and (ii) pH 7 (SIDtp), and further injection-moulded into a desired shape. During the extrusion...
Dynamic mechanical properties of hydroxyapatite-reinforced and porous starch-ba...
Mano, J. F.; Vaz, Cláudia M.; Mendes, Sandra C.; Reis, R. L.; Cunha, A. M.It has been shown that blends of starch with a poly(ethylene-vinyl-alcohol) copolymer, EVOH, designated as SEVA-C, present an interesting combination of mechanical, degradation and biocompatible properties, specially when filled with hydroxyapatite (HA). Consequently, they may find a range of applications in the biomaterials field. This work evaluated the influence of HA fillers and of blowing agents (used to p...
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