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Psychosocial adjustment, psychiatric morbidity and quality of life in adolescen...
Coelho, Rosália; Teixeira, Flávio; Silva, Ana; Vaz, Cláudia; Vieira, Daniela; Proença, Cidália; Moura, Cláudia; Viana, Victor; Areias, JoséObjectives We aimed to study the psychosocial adjustment (PSA), psychiatric morbidity and quality of life of adolescents and young adults with congenital heart disease (CHD) to determine which demographic and clinical variables negatively affect adjustment and which increase resilience. Methods The study included 74 patients with CHD, 41 male and 33 female, aged between 12 and 26 years (mean 18.76±3.86). Demogr...
Quality of Life Experienced by Adolescents and Young Adults with Congenital Hea...
Teixeira, Flávio; Coelho, Rosália; Proença, Cidália; Silva, Ana; Vieira, Daniela; Vaz, Cláudia; Moura, Cláudia; Viana, Victor; Areias, JoséThis study aimed to assess the quality of life (QOL) experienced by adolescents and young adults with congenital heart disease (CHD) and to determine which factors negatively affect adjustment and which factors increase resilience. The participants in the study were 74 patients with CHD (41 males and 33 females) ranging in age from 12 to 26 years (mean age, 18.76 ± 3.86 years). Demographic information and a com...
Quality of life of patients with congenital heart diseases
Silva, Ana; Vaz, Cláudia; Areias, Maria; Vieira, Daniela; Proenca, Cidália; Viana, Victor; Moura, Cláudia; Areias, JoséObjectives: To assess the perception of the quality of life of adolescents and young adults with congenital heart disease and to examine the variables that have a negative impact on it and that add a resilience effect. Methods: A total of 22 male and 18 female patients, aged 12–26 years, of whom 27 were admitted to surgery and 13 were not, participated in this study. All patients had complete medical reco...
Controlled delivery achieved with bi-layer matrix devices produced by co-inject...
Vaz, Cláudia M.; Doeveren, P. F. N. M. van; Dias, Gustavo R.; Reis, R. L.; Cunha, A. M.The aim of this study was to design new soy protein-based bi-layered co-injection moulded matrix systems aimed to achieve controlled drug delivery. The devices consisted of a drug-free outer layer (skin) and a drug-containing core. The systems overcame the inherent disadvantage of non-linear release associated with diffusion-controlled single-layer matrix devices by providing additional releasing area with time...
Effect of crosslinking, thermal treatment and UV irradiation on the mechanical ...
Vaz, Cláudia M.; Graaf, L. A. de; Reis, R. L.; Cunha, A. M.Gelatine (GEL), soy (SI), casein (CAS) and sodium-caseinate (NaCAS) solutions were cast to produce protein films. All the proteins were chemically modified by adding glyoxal to the film-forming solutions in amounts varying from 0 to 0.9% (w/w based on the protein content). After casting, the same films were also submitted to a heat treatment performed at 80 °C or UV irradiation. The effect of those chemical/phy...
In vitro degradation and cytocompatibility evaluation of novel soy and sodium c...
Silva, G. A.; Vaz, Cláudia M.; Coutinho, O. P.; Cunha, A. M.; Reis, R. L.Soy- and casein-based membranes are newly proposed materials disclosing a combination of properties that might allow for their use in a range of biomedical applications. Two of the most promising applications are drug delivery carrier systems and wound dressing membranes. As for all newly proposed biomaterials, a cytotoxic scanning must be performed as a preliminary step in the process of the determination of t...
Soy matrix drug delivery systems obteined by melt-processing techniques
Vaz, Cláudia M.; Doeveren, P. F. N. M. van; Reis, R. L.; Cunha, A. M.The aim of this study was to develop new soy protein drug delivery matrix systems by melt-processing techniques, namely, extrusion and injection moulding. The soy matrix systems with an encapsulated drug (theophylline, TH) were previously compounded by extrusion performed at two different pH values, (i) pH 4 (SIpDtp) and (ii) pH 7 (SIDtp), and further injection-moulded into a desired shape. During the extrusion...
Dynamic mechanical properties of hydroxyapatite-reinforced and porous starch-ba...
Mano, J. F.; Vaz, Cláudia M.; Mendes, Sandra C.; Reis, R. L.; Cunha, A. M.It has been shown that blends of starch with a poly(ethylene-vinyl-alcohol) copolymer, EVOH, designated as SEVA-C, present an interesting combination of mechanical, degradation and biocompatible properties, specially when filled with hydroxyapatite (HA). Consequently, they may find a range of applications in the biomaterials field. This work evaluated the influence of HA fillers and of blowing agents (used to p...
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