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Exploring bioactive properties of marine cyanobacteria Isolated from the Portug...
Costa, Margarida; Garcia, Mónica; Costa-Rodrigues, João; Costa, Maria Sofia; Ribeiro, Maria João; Fernandes, Maria Helena; Barros, PiedadeThe oceans remain a major source of natural compounds with potential in pharmacology. In particular, during the last few decades, marine cyanobacteria have been in focus as producers of interesting bioactive compounds, especially for the treatment of cancer. In this study, the anticancer potential of extracts from twenty eight marine cyanobacteria strains, belonging to the underexplored picoplanktonic genera, C...
Antitumor activity of hierridin B, a cyanobacterial secondary metabolite found ...
Leão, Pedro N.; Costa, Margarida; Ramos, Vitor; Pereira, Alban R.; Fernandes, Virginia C.; Domingues, Valentina F.; Gerwick, William H.Cyanobacteria are widely recognized as a valuable source of bioactive metabolites. The majority of such compounds have been isolated from so-called complex cyanobacteria, such as filamentous or colonial forms, which usually display a larger number of biosynthetic gene clusters in their genomes, when compared to free-living unicellular forms. Nevertheless, picocyanobacteria are also known to have potential to pr...
Antitumor activity of hierridin B, a cyanobacterial secondary metabolite found ...
Leão, Pedro N.; Costa, Margarida; Ramos, Vitor; Pereira, Alban R.; Fernandes, Virgínia C.; Domingues, Valentina F.; Gerwick, William H.Cyanobacteria are widely recognized as a valuable source of bioactive metabolites. The majority of such compounds have been isolated from so-called complex cyanobacteria, such as filamentous or colonial forms, which usually display a larger number of biosynthetic gene clusters in their genomes, when compared to free-living unicellular forms. Nevertheless, picocyanobacteria are also known to have potential to pr...
Evaluation of phylogenetic markers suitable for Planktothrix spp. discrimination
Menezes, Carina; Churro, Catarina; Pereira, Paulo; Vasconcelos, Vitor; Valério, ElisabeteIn Portugal, potentially toxic cyanobacteria from Planktothrix genus have become frequently observed in freshwater reservoirs. Identification of Planktothrix species through optical microscopy is complicated due to limited morphological differences among them. The aim of this work was to determine the most suitable phylogenetic markers that could be used for the molecular identification of Planktothrix species....
The role of sanctioning in the evolutionary dynamics of collective action
Vasconcelos, Vítor Vasco Lourenço deTese de mestrado em Física, apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2012 ; Preventing global warming requires overall cooperation. Contributions will depend on the risk of future losses, which plays a key role in decision making. Here, I discuss an evolutionary game theoretical model in which decisions within small groups under high risk and stringent requirements toward success...
Marine cyanobacteria compounds with anticancer properties: a review on the impl...
Costa, Margarida; Costa-Rodrigues, João; Fernandes, Maria Helena; Barros, Piedade; Vasconcelos, Vitor; Martins, RosárioMarine cyanobacteria have been considered a rich source of secondary metabolites with potential biotechnological applications, namely in the pharmacological field. Chemically diverse compounds were found to induce cytoxicity, anti-inflammatory and antibacterial activities. The potential of marine cyanobacteria as anticancer agents has however been the most explored and, besides cytotoxicity in tumor cell lines,...
Are known cyanotoxins involved in the toxicity of picoplanktonic and filamentou...
Frazão, Bárbara; Martins, Rosário; Vasconcelos, VitorEight marine cyanobacteria strains of the genera Cyanobium, Leptolyngbya, Oscillatoria, Phormidium, and Synechococcus were isolated from rocky beaches along the Atlantic Portuguese central coast and tested for ecotoxicity. Strains were identified by morphological characteristics and by the amplification and sequentiation of the 16S rDNA. Bioactivity of dichloromethane, methanol and aqueous extracts was assessed...
Primary screening of the bioactivity of brackishwater cyanobacteria: toxicity o...
Lopes, Viviana; Fernandez, Nuria; Martins, Rosário; Vasconcelos, VitorCyanobacteria are a diverse group of Gram-negative bacteria that produce an array of secondary compounds with selective bioactivity against vertebrates, invertebrates, plants, microalgae, fungi, bacteria, viruses and cell lines. The aim of this study was to assess the toxic effects of aqueous, methanolic and hexane crude extracts of benthic and picoplanktonic cyanobacteria isolated from estuarine environments, ...
Antimicrobial and cytotoxic assessment of marine cyanobacteria - synechocystis ...
Martins, Rosário; Ramos, Miguel; Herfindal, Lars; Sousa, José; Skærven, Kaja; Vasconcelos, VitorAqueous extracts and organic solvent extracts of isolated marine cyanobacteria strains were tested for antimicrobial activity against a fungus, Gram-positive and Gram-negative bacteria and for cytotoxic activity against primary rat hepatocytes and HL-60 cells. Antimicrobial activity was based on the agar diffusion assay. Cytotoxic activity was measured by apoptotic cell death scored by cell surface evaluation a...
Toxicologia de cianobactérias : Distribuição de cianobactérias tóxicas e suas t...
Vasconcelos, Vítor Manuel de Oliveira eDissertação de Doutoramento em Biologia, área de especialização em Ecologia Aplicada, apresentada à Faculdade de Ciências da Universidade do Porto
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