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Suillus luteus methanolic extract inhibits proliferation and increases expressi...

Methanolic extract of Suillus luteus was previously shown to inhibit proliferation of colon cancer cells with mutant p53. The effect of the same extract was further investigated here in a wildtype (wt) p53 non-small cell lung cancer cell line. Treatment with the extract increased the levels of p-H2A.X and the number of p-H2A.X foci/cell, indicating a possible increase in deoxyribonucleic acid (DNA) damage. Neve...

Flower extracts of Filipendula ulmaria (L.) Maxim inhibit the proliferation of ...

Filipendula ulmaria (L.) Maxim (meadowsweet) is a popular medicinal species that can be found throughout most Europe and Asia. The plant is known for its rich antioxidants content, having compounds such as flavonoids and ascorbic acid. Therefore, the aim of this work was to investigate if the flower extracts of F. ulmaria (L.) Maxim have cell growth inhibitory activity in three human tumour cell lines represent...

A methanolic extract of Ganoderma lucidum fruiting body inhibits the growth of ...

Ganoderma lucidum is one of the most extensively studied mushrooms as a functional food and as a chemopreventive agent due to its recognized medicinal properties. Some G. lucidum extracts have shown promising antitumor potential. In this study, the bioactive properties of various extracts of G. lucidum, from both the fruiting body and the spores, were investigated. The most potent extract identified was the met...

Gonoderma luicidium methanolic extract : chemical characterization in phenolic ...

Composite pressure vessels for commercial applications

A new generation of composite pressure vessels for large scale market applications has been studied in this work. The vessels consist on a plastic liner wrapped with a filament winding glass fibre reinforced polymer matrix structure. A polyethylene (PE) was selected as liner for water at room temperatures applications and a thermosetting resin was used as matrices in the glass reinforced filament wound laminate...

Suillus luteus methanolic extract inhibits cell growth and proliferation of a c...

Several edible mushrooms extracts are known to have tumour cell growth inhibitory potential. The objective of this work was to study this potential in extracts of Suillus luteus collected from the Northeast of Portugal. Various extracts were prepared and their effect on tumour cell growth was studied with the SRB assay in four human tumour cell lines: MCF-7 (breast), NCI-H460 (non-small cell lung cancer), AGS (...

Estudo de propriedades antioxidantes, antiproliferativas e indutoras de apoptos...

Os cogumelos são um importante recurso complementar de ecossistemas florestais e outros, com propriedades nutricionais e medicinais milenarmente reconhecidas. O objetivo deste trabalho foi a avaliação das propriedades bioativas (antioxidantes e potencial inibidor de crescimento de linhas celulares tumorais humanas) de cogumelos silvestres comestíveis provenientes do Nordeste de Portugal. Prepararam-se extratos ...

New di(hetero)arylethers and di(hetero)arylamines in the thieno[3,2-b]pyridine ...

New fluorinated and methoxylated di(hetero)arylethers and di(hetero)arylamines were prepared functionalizing the 7-position of the thieno[3,2-b]pyridine, using copper (C–O) or palladium (C–N) catalyzed couplings, respectively, of the 7-bromothieno[3,2-b]pyridine, also prepared, with ortho, meta and para fluoro or methoxy phenols and anilines. The compounds obtained were evaluated for their growth inhibitory act...

Síndrome de Miller Fisher numa criança

Introdução: O síndrome de Miller Fisher, variante do síndrome de Guillain-Barré, é uma doença desmielinizante inflamatória aguda, que é rara em idade pediátrica. O seu diagnóstico é baseado na tríade oftalmoplegia, ataxia e arreflexia. Em cerca de metade dos casos está descrita uma intercorrência infecciosa precedendo os sintomas neurológicos em cinco a dez dias. Caso clínico: Os autores relatam o caso de uma c...

Aminodi(hetero)arylamines in the thieno[3,2-b]pyridine series : synthesis, effe...

Three aminodi(hetero)arylamines were prepared via a palladium-catalyzed C-N Buchwald-Hartwig coupling of methyl 3-aminothieno[3,2-b]pyridine-2-carboxylate with different bromonitrobenzenes, followed by reduction of the nitro groups of the coupling products to the corresponding amino compounds. The aminodi(hetero)arylamines thus obtained were evaluated for their growth inhibitory effect on four human tumor cell ...