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Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: A pos...
Teodoro, João Soeiro; Duarte, Filipe Valente; Gomes, Ana Patrícia; Varela, Ana Teresa; Peixoto, Francisco Manuel; Rolo, Anabela Pinto; Palmeira, C. M.Berberine is an isoquinoline alkaloid with anti-diabetic properties. Despite the central role of liver and thus hepaticmitochondria inwhole-bodymetabolism, berberine effects on hepaticmitochondrial function in an obesity model are still unknown. Here, we demonstrate that berberine treatment recovers mitochondrial efficiency when altered by a high-fat feeding.Mitochondria isolated from the liver of high-fat fed ...
Regulation of Mitochondrial Function in Ischemia/Reperfusion: Looking for Thera...
Varela, Ana Teresa Inácio FerreiraNon-alcoholic fatty liver diseases (NAFLD) are associated with obesity and type II diabetes, which are rapidly increasing worldwide due to a fat rich diet and lack of exercise. Fatty liver is characterized by the accumulation of fat in the cytoplasm of hepatocytes derived from adipocytes, intestinal absorption or hepatic lipogenesis. Clinical data has shown that fatty livers are more susceptible to ischemia/ re...
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