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Lead toxicity in Saccharomyces cerevisiae

The effect of Pb on Saccharomyces cerevisiae cell structure and function was examined. Membrane integrity was assessed by the release of UV-absorbing compounds and by the intracellular K+ efflux. No leakage of UV260-absorbing compounds or loss of K+ were observed in Pb (until 1,000 μmol/l) treated cells up to 30 min; these results suggest that plasma membrane seems not to be the immediate and primary target of ...