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Bone response and mechanical strength of rabbit femoral defects filled with inj...
Link, Dennis P.; Van den Dolder, Juliette; Van den Beucken, Jeroen J.; Wolke, Joop G.; Mikos, Antonios G.; Jansen, John A.This study focused at the potential of transforming growth factor β1 (TGF-β1) loaded gelatin microparticles to enhance the bone response and mechanical strength of rabbit femoral defects filled with injectable calcium phosphate (CaP)/gelatin microparticle composites. Therefore, TGF-β1 loaded composites and non-loaded controls were injected in circular defects as created in the femoral condyles of rabbits and we...
The cytocompatibility and early osteogenic characteristics of an injectable cal...
Link, Dennis P.; Van den Dolder, Juliette; Van den Beucken, Jeroen J.; Jansen, John A.In this study, the cytocompatibility and early osteogenic characteristics of rat bone marrow cells (RBMCs) on injectable calcium phosphate (CaP) cement (Calcibon) were investigated. In addition to unmodified CaP cement discs, 2 other treatments were given to the discs: preincubation in MilliQ and sintering at different temperatures. After primary culture, RBMCs were dropwise seeded on the discs and cultured for...
Bone regenerative properties of injectable PGLA-CaP composite with TGF-beta1 in...
Plachokova, A.; Link, Dennis P.; Van den Dolder, Juliette; Van den Beucken, Jeroen J.; Jansen, John A.The aim of this study was to examine the bone augmentation properties of an injectable composite consisting of PLGA microspheres/CaP cement (20/80), and the additional effect of loading PLGA microspheres with TGF-β1 (200 ng). For this purpose, PLGA/CaP composites (control) and PLGA/CaP composites loaded with TGF-β1 (test group) were injected on top of the skulls of 24 Wistar rats. Each rat received 2 materials ...
Mechanical evaluation of implanted calcium phosphate cement incorporated with P...
Link, Dennis P.; Van den Dolder, Juliette; Jurgens, J. F. M.; Wolke, Joop G.; Jansen, John A.In this study, the mechanical properties of an implanted calcium phosphate (CaP) cement incorporated with 20wt% poly (DL-lactic-coglycolic acid) (PLGA) microparticles were investigated in a rat cranial defect. After 2, 4 and 8 weeks of implantation, implants were evaluated mechanically (push-out test) and morphologically (Scanning Electron Microscopy (SEM) and histology). The results of the push-out test showed...
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