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Novel methodology based on biomimetic superhydrophobic substrates to immobilize...
Lima, A. C.; Batista, P.; Valente, T.; Silva, A. S.; Correia, I. J.; Mano, J. F.Cell-based therapies for regenerative medicine have been characterized by the low retention and integration of injected cells into host structures. Cell immobilization in hydrogels for target cell delivery has been developed to circumvent this issue. In this work mesenchymal stem cells isolated from Wistar rats bone marrow (rMSCs) were immobilized in alginate beads fabricated using an innovative approach involv...
Novel methodology based on biomimetic superhydrophobic substrates to immobilize...
Lima, A. C.; Batista, P.; Valente, T.; Silva, A. S.; Correia, I. J.; Mano, J. F.The low retention/integration of injected cells by host structures represents an important challenge in cell based therapies for regenerative medicine purposes. Cell immobilization in hydrogels for target cell delivery has been developed to circumvent this issue. However, the existing immobilization methodologies sometimes have several steps under wet conditions and present some drawbacks, including poor encaps...
One year of Lamivudine therapy for portuguese patients with chronic hepatitis B.
Areias, J; Calinas, F; Porto, A; Carvalho, A; Freitas, D; Macedo, G; Noronha, R; Cotter, J; Meliço-Silvestre, A; Peixe, R; Pratas, J; Barrote, DOBJECTIVE: To further verify the efficacy and safety of locally manufactured lamivudine on patients with chronic hepatitis B (CHB). METHODS: 2200 patients with CHB were recruited and received lamivudine orally 100 mg once daily for 12 months. The efficacy assessments included virologic response rate (defined by the absence of serum HBV DNA, HBeAg loss and HBeAg/HBeAb seroconversion), percentage of patients wit...
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