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The ulcerogenic profile of Helicobacter pylori paediatric strains associated wi...
Vitoriano, Inês; Saraiva-Pava, Kathy; Rocha-Gonçalves, António; Alves-Matos, Pedro; Vale, Filipa; Santos, Andrea; Lopes, Ana Isabel; Oleastro, MónicaHelicobacter pylori infection is the major cause of paediatric peptic ulcer disease (PUD). In children with no other aetiology for the disease, this rare event occurs shortly after infection, presuming a still poorly understood higher susceptibility of the patient and highlighting the virulence of the implicated strain. Recently, we showed that the enhanced virulence of a group of paediatric ulcerogenic-strains...
Screening of Prophage Sequences Among Helicobacter Pylori
Timóteo, Andreia; Breurec, S.; Oleastro, Mónica; Roxo-Rosa, Mónica; Vítor, Jorge; Lehours, Phillipe; Vale, FilipaUntil recently, Helicobacter pylori was considered a bacterium without prophages. The presence of an incomplete prophage sequence in strain B38 and a complete prophage sequence in strain B45 showed otherwise. Using a PCR strategy, based on degenerated primers designed after aligning bacteriophage integrase genes from H. pylori strains B38 and B45, and H. acinonychis prophage II, we found that integrase sequence...
Proteome analysis of clustered helicobacter pylori strains
Vitoriano, Inês; Vítor, Jorge; Oleastro, Mónica; Roxo-Rosa, Mónica; Vale, FilipaGenomic-methylation typing method, based on strains’ Restriction/Modification systems, confirmed the genetic variability of Helicobacter pylori. According to this, strains isolated from patients of the same family, or from the same geographic region, cluster together. The analysis of proteome’s variability of these clusters has been a missing topic. We applied the Minimum-Common-Restriction-Modification (MCRM) ...
Geographic distribution of methyltransferases of Helicobacter pylori: evidence ...
Vale, Filipa; Mégraud, Francis; Vítor, Jorge M. B.Background Helicobacter pylori colonizes the human stomach and is associated with gastritis, peptic ulcer, and gastric cancer. This ubiquitous association between H. pylori and humans is thought to be present since the origin of modern humans. The H. pylori genome encodes for an exceptional number of restriction and modifications (R-M) systems. To evaluate if R-M systems are an adequate tool to determine the ge...
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