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NMR analysis of a series of substituted pyrazolo[3,4-d]pyrimidines-4-amines

Rodrigues, Lígia M.; Sivasubramanian, Aravind; Pinto, Elisa M. M. S.; Campos, Ana M. F. Oliveira; Seijas, Julio A.; Vázquez-Tato, M. Pilar

A series of twenty one substituted pyrazolo[3,4-d]pyrimidines-4-amines were studied by 1H and 13C NMR. The application of two-dimensional techniques, HMQC and HMBC, allowed the complete assignment of the spectra for all the compounds.


Substituted pyrazolo[3,4-d]pyrimidines : microwave assisted, solvent free synth...

Campos, Ana M. F. Oliveira; Sivasubramanian, Aravind; Rodrigues, Lígia M.; Seijas, Julio A.; Vázquez-Tato, M. Pilar; Peixoto, Francisco

A simple and efficient method has been developed for the synthesis of various pyrazolo[3,4-d]pyrimidines using microwave irradiation under solvent-free conditions. The advantages of applying microwave irradiation compared with the classical method were demonstrated. The structures of all the compounds were confirmed by the usual techniques and in two cases by X-ray analysis. The compounds did not display apprec...


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