Encontrados 16 documentos, a visualizar página 1 de 2
Enzymatic degradation behavior and cytocompatibility of silk fibroin–starch–chi...
Baran, E. T.; Tuzlakoglu, K.; Mano, J. F.; Reis, R. L.The objective of this study was to investigate the influence of silk fibroin and oxidized starch conjugation on the enzymatic degradation behavior and the cytocompatability of chitosan based biomaterials. The tensile stress of conjugate membranes, which was at 50 Megapascal (MPa) for the lowest fibroin and starch composition (10 weight percent (wt.%)), was decreased significantly with the increased content of f...
Microchannel-patterned and heparin micro-contact-printed biodegradable composit...
Baran, Erkan Türker; Tuzlakoglu, K.; Salgado, A. J.; Reis, R. L.Microchannel-patterned starch–poly(capro-lactone)/hydydroxyapatite (SPCL–HA) and starch– poly(lactic acid) (SPLA) composite membranes were produced for use as a laminated tissueengineering scaffold that incorporates both physical and biochemical patterns. For this purpose, SPCL (30% starch) blended with inorganic hydroxyl apatite (50%) and SPLA (50% starch) membranes were made with compressive moulding. Consequ...
Design of nano- and microfiber combined scaffolds by electrospinning of collage...
Tuzlakoglu, K.; Santos, Marina I.; Neves, N. M.; Reis, R. L.Mimicking the structural organization and biologic function of natural extracellular matrix has been one of the main goals of tissue engineering. Nevertheless, the majority of scaffolding materials for bone regeneration highlights biochemical functionality in detriment of mechanical properties. In this work we present a rather innovative construct that combines in the same structure electrospun type I collagen ...
In vivo short and long term host reaction to starch-based scaffolds
Santos, T. C.; Marques, A. P.; Hoering, B.; Martins, A. R.; Tuzlakoglu, K.; Castro, António G.; Griensven, Martijn van; Reis, R. L.The implantation of biomaterials may elicit a host response to this foreign body, and the magnitude of that reaction depends on the host and on the implanted material. The aim of this study was to compare the inflammatory response induced by the implantation of starch-based (SPCL) scaffolds in two implantation rat models: subcutaneous (SC) and intramuscular (IM). Moreover, two methodologies, wet spinning (WS) a...
A new route to produce starch-based fiber mesh scaffolds by wet spinning and su...
Tuzlakoglu, K.; Pashkuleva, I.; Rodrigues, Márcia T.; Gomes, Manuela E.; Lenthe, G. H. van; Müler, R.; Reis, R. L.This study proposes a new route for producing fiber mesh scaffolds from a starch-polycaprolactone (SPCL) blend. It was demonstrated that the scaffolds with 77% porosity could be obtained by a simple wet-spinning technique based on solution/precipitation of a polymeric blend. To enhance the cell attachment and proliferation, Ar plasma treatment was applied to the scaffolds. It was observed that the surface morph...
Preparation and characterization of starch-poly-epsilon-caprolactone microparti...
Balmayor, Elizabeth Rosado; Tuzlakoglu, K.; Azevedo, Helena S.; Reis, R. L.One limitation associated with the delivery of bioactive agents concerns the short half-life of these molecules when administered intravenously, which results in their loss from the desired site. Incorporation of bioactive agents into depot vehicles provides a means to increase their persistence at the disease site. Major issues are involved in the development of a proper carrier system able to deliver the corr...
Biodegradable polymeric fiber structures in tissue engineering
Tuzlakoglu, K.; Reis, R. L.Tissue engineering offers a promising new approach to create biological alternatives to repair or restore function of damaged or diseased tissues. To obtain three-dimensional tissue constructs, stem or progenitor cells must be combined with a highly porous three-dimensional scaffold, but many of the structures purposed for tissue engineering cannot meet all the criteria required by an adequate scaffold because ...
Incorporation of a sequential BMP-2/BMP-7 delivery system into chitosan-based s...
Yilgor, Pinar; Tuzlakoglu, K.; Reis, R. L.; Hasirci, N.; Hasirci, VasifThe aim of this study was to develop a 3-D construct carrying an inherent sequential growth factor delivery system. Poly(lactic acid-co-glycolic acid) (PLGA) nanocapsules loaded with bone morphogenetic protein BMP-2 and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanocapsules loaded with BMP-7 made the early release of BMP-2 and longer term release of BMP-7 possible. 3-D fiber mesh scaffolds were prepar...
Endothelial cell colonization and angiogenic potential of combined nano- and mi...
Santos, Marina I.; Tuzlakoglu, K.; Fuchs, Sabine; Gomes, Manuela E.; Peters, K.; Piskin, Erhan; Reis, R. L.; Kirkpatrick, C. James; Unger, Ronald E.Presently the majority of tissue engineering approaches aimed at regenerating bone relies only on postimplantation vascularization. Strategies that include seeding endothelial cells (ECs) on biomaterials and promoting their adhesion, migration and functionality might be a solution for the formation of vascularized bone. Nano/micro-fiber-combined scaffolds have an innovative structure, inspired by extracellular ...
Fiber-based structures from natural origin polymers for tissue engineering appr...
Tuzlakoglu, K.Tese de doutoramento em Ciência e Tecnologia de Materiais - Área de Biomateriais. ; Tissue engineering is a new concept emerged as an alternative approach to tissue and organ reconstruction. It differs from organ transplantation by regenerating patient’s own tissue and organs avoiding the biocompatibility and low biofunctionality problems as well as severe immune rejection; which are the main problems of organ...
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