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IFNAR1 Controls Progression to Cerebral Malaria in Children and CD8+ T Cell Bra...
Ball, E. A.; Sambo, M. R.; Martins, M.; Trovoada, M. J.; Benchimol, C.; Costa, J.; Antunes Goncalves, L.; Coutinho, A.; Penha-Goncalves, C.Malaria in pregnancy is exquisitely aggressive, causing a range of adverse maternal and fetal outcomes prominently linked to Plasmodium-infected erythrocyte cytoadherence to fetal trophoblast. To elucidate the physiopathology of infected erythrocytes (IE) sequestration in the placenta we devised an experimental system for intravital placental examination of P. berghei-infected mice. BALB/c females were mated to...
Allele frequencies of 6 STR loci (TH01, TPOX, CSF1PO, D13S317, D16S539 and D7S8...
Manco, Licínio; Silva, Isabel; Arede, Pedro; Jesus Trovoada, M.; Abade, Augusto; Alvarez, ManuelaAllele frequencies of six autosomal short tandem repeat (STR) markers (TH01, TPOX, CSF1PO, D13S317, D7S820 and D16S539) were estimated in a population sample (N=53-85) of unrelated individuals from São Tomé e Principe (West Africa). No deviations from Hardy-Weinberg equilibrium were observed for all loci. Allele frequency distribution and heterozygosity values were similar with those from other sub-Saharan Afri...
Pattern of mtDNA Variation in Three Populations from São Tomé e Príncipe
Trovoada, M. J.; Pereira, L.; Gusmão, L.; Abade, A.; Amorim, A.; Prata, M. J.We have analysed the matrilineal genetic composition of three self-reported ethnic groups from São Tomé e Príncipe (Gulf of Guinea), an African archipelago whose settlement begun in the late fifteenth century. Sequence data from the hypervariable segments I (HVS-I) and II (HVS-II) were obtained for 30 Angolares, 35 Forros and 38 Tongas. The repertory of mtDNA lineages in São Tomé e Príncipe denoted a fully Afri...
Evidence for population sub-structuring in São Tomé e Príncipe as inferred from...
Trovoada, M. J.; Alves, C.; Gusmão, L.; Abade, A.; Amorim, A.; Prata, M. J.Seven Y-chromosome STR loci, DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392 and DYS393 have been analysed in population samples of Angolares, Forros and Tongas, three ethnic groups from the African archipelago of São Tomé e Príncipe (Gulf of Guinea). Complete typings were obtained for 103 chromosomes, which belonged to 79 different haplotypes. The mean heterozygosity per locus in the overall São Tomean sample...
Distribution of AMY2 polymorphism in S. Tomé and Príncipe (West Africa)
Manco, L.; Trovoada, M.; Abade, A.; Amorim, A.Abstract The genetic polymorphism of AMY2 was studied in the population of S. Tom and Prncipe (West Africa) using agarose gel electrophoresis. AMY2 frequencies are reported for the first time in a subSaharian population. The gene frequencies found were: AMY2*1=0.948, AMY2*3=0.052 (N=173). ; http://dx.doi.org/10.1007/BF02447634
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