Encontrados 2 documentos, a visualizar página 1 de 1
Molecular genetics of papillary thyroid carcinoma: great expectations...
Trovisco,Vítor; Soares,Paula; Preto,Ana; Castro,Patrícia; Máximo,Valdemar; Sobrinho-Simões,ManuelPapillary thyroid carcinoma (PTC) is the most prevalent type of endocrine cancer and, in recent epidemiological surveys, one of the types of human cancer whose incidence is growing. Despite the favourable outcome and long survival rates of most patients, some tumours display an aggressive behaviour and may progress to the highly aggressive and lethal, anaplastic thyroid carcinoma. In recent years, several progr...
Mutation analysis of B-RAF gene in human gliomas
Basto, Diana; Trovisco, Vítor; Lopes, José M.; Martins, Albino; Pardal, Fernando; Soares, Paula; Reis, R. M.The RAS/RAF/MEK/ERK kinase pathway is pivotal in the transduction of mitogenic stimuli from activated growth factor receptors, which regulates cell proliferation, survival, and differentiation. Up-regulation of this pathway due to RAS mutations is found in approximately 30% of human tumors. Recently, activating mutations of B-RAF were identified in a large proportion of human cancers. Gliomas are the most frequ...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||