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Phage therapy is effective against infection by Mycobacterium ulcerans in a mur...
Trigo, Gabriela; Martins, Teresa G.; Fraga, Alexandra G.; Longatto Filho, Adhemar; Castro, António G.; Azeredo, Joana; Pedrosa, JorgeAuthor Summary : Buruli Ulcer (BU), caused by Mycobacterium ulcerans, is a necrotizing disease of the skin, subcutaneous tissue and bone. Standard treatment of BU patients consists of a combination of the antibiotics rifampicin and streptomycin for 8 weeks. However, in advanced stages of the disease, surgical resection of the destroyed skin is still required. The use of bacterial viruses (bacteriophages) for th...
Innovative anti-microbial strategies against buruli ulcer : bacteriophage therapy
Trigo, Gabriela; Martins, Teresa G.; Oliveira, Hugo; Fraga, Alexandra G.; Castro, António G.; Azeredo, Joana; Pedrosa, Jorge
Corticosteroid-Induced Immunosuppression ultimately does not compromise the eff...
Martins, Teresa G.; Trigo, Gabriela; Fraga, Alexandra G.; Gama, José B.; Longatto Filho, Adhemar; Saraiva, Margarida; Silva, Manuel T.The authors would like to thank Luis Martins, Deolinda Teixeira and Miguel Carneiro for laboratory assistance. Conceived and designed the experiments: TGM MS MTS AGC JP. Performed the experiments: TGM GT AGF JBG ALF. Analyzed the data: TGM ALF MS MTS AGC JP. Contributed reagents/materials/analysis tools: TGM MS MTS AGC JP. Wrote the paper: TGM AGF ALF MS MTS AGC JP. ; Buruli ulcer (BU) is a necrotizing disease...
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