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Trissomia 21 : como é que a família e a escola podem Intervir para promover o d...
Torres, Susana Maria CorreiaO presente trabalho resulta de um estudo teórico sobre as crianças portadoras de síndrome de Down, partindo da seguinte questão: como é que a família e a escola podem intervir para promover o desenvolvimento da linguagem na criança com síndrome de Down? Para tal, iremos pesquisar vários autores para orientar esta investigação. Descrevem-se nela notas e conceitos fundamentais para o desenvolvimento integral da c...
H5EPTPACH2OH: Synthesis, Relaxometric Characterization and 1H NMR Spectroscopic...
Torres, Susana; Martins, José A.; André, João P.; Pereira, Giovannia A.; Kiraly, Robert; Brücher, Ernö; Helm, Lothar; Tóth, ÉvaThe synthesis and characterization of a new metal chelator, 4-(S)-hydroxymethyl-3,6,10-tri(carboxymethyl)-3,6,10-triazadodecanedioic acid (H5EPTPACH2OH), is reported. Protonation constants for the ligand H5EPTPACH2OH and for the previously reported H5EPTPAC16 have been determined by potentiometry, which reveals that both ligands display slightly higher protonation constants relative to that of the ligand DTPA5-...
Supramolecular Assembly of an Amphiphilic GdIII Chelate: Tuning the Reorientati...
Torres, Susana; Martins, José A.; André, João P.; Geraldes, Carlos F. G. C.; Merbach, André E.; Tóth, ÉvaWe report the synthesis and characterization of the novel ligand H5EPTPA-C16 ((hydroxymethylhexadecanoyl ester)ethylenepropylenetriaminepentaacetic acid). This ligand was designed to chelate the GdIII ion in a kinetically and thermodynamically stable way while ensuring an increased water exchange rate (kex) on the GdIII complex owing to steric compression around the water-binding site. The attachment of a palmi...
Targeting of lanthanide(III) chelates of DOTA-type glycoconjugates to the hepat...
Prata, M. I. M.; Santos, A. C.; Torres, Susana; André, João P.; Martins, J. A. R.; Neves, M.; García Martín, M. L.; Rodrigues, T. B.; López Larrubia, P.The characterization of a new class of hydrophilic liver-targeted agents for gamma-scintigraphy and MRI, consisting, respectively, of [153Sm]3+ or Gd3+ complexes of DOTA monoamide or bisamide linked glycoconjugates (DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), is reported. In vitro studies show high uptake of radiolabeled 153SmDOTAGal2 by the human hepatocyte carcinoma cell line Hep G2 cont...
Supramolecular assembly of an amphiphilic GdIII chelate : tuning the reorientat...
Torres, Susana; Martins, J. A. R.; André, João P.; Geraldes, Carlos F. G. C.; Merbach, André E.; Tóth, ÉvaIn this paper we report the synthesis and the characterization of the novel ligand H5EPTPA-C16 ((hydroxymethylhexadecanoyl ester)ethylenepropylenetriaminepentaacetic acid). This ligand was designed to chelate the GdIII ion in a kinetically and thermodynamically stable way while ensuring an increased water exchange rate (kex) on the GdIII complex due to steric compression around the water binding site. The attac...
Combining context and contents description in multimedia archives
Maria Cristina Ribeiro; Gabriel David; José Torres; Susana Gaio
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