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Competition between lithium and magnesium ions for the G-protein transducin in ...
Srinivasan, Chandra; Toon, Jason; Amari, Louis; Abukhdeir, Abde M.; Hamm, Heidi; Geraldes, Carlos F. G. C.; Ho, Yee-Kin; Freitas, Duarte Mota deLi+ is the most effective drug used to treat bipolar disorder; however, its exact mechanism of action has yet to be elucidated. One hypothesis is that Li+ competes with Mg2+ for the Mg2+ binding sites on guanine-nucleotide binding proteins (G-proteins). Using 7Li T1 relaxation measurements and fluorescence spectroscopy with the Mg2+ fluorophore furaptra, we detected Li+/Mg2+ competition in three preparations: t...
Competition between Na+ and Li+ for Unsealed and Cytoskeleton-Depleted Human Re...
Srinivasan, Chandra; Minadeo, Nicole; Toon, Jason; Graham, Daniel; Freitas, Duarte Mota de; Geraldes, Carlos F. G. C.Evidence for competition between Li+ and Na+ for binding sites of human unsealed and cytoskeleton-depleted human red blood cell (csdRBC) membranes was obtained from the effect of added Li+ upon the 23Na double quantum filtered (DQF) and triple quantum filtered (TQF) NMR signals of Na+-containing red blood cell (RBC) membrane suspensions. We found that, at low ionic strength, the observed quenching effect of Li+...
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