Aiming at contributing to the understanding the molecular level mechanisms governing the behavior of biocompounds in aqueous saline environments, experimental solubility measurements and molecular dynamics (MD) simulations were performed for aqueous solutions of three amino acids (alanine, valine and isoleucine) in the presence of a series of inorganic salts.
Separation and concentration of biological compounds are current subjects of interest due to their high cost in comparison to the total manufacture cost. For that purpose electrolytes may be employed as they can effect significantly biochemicals solubilities, a feature that has been used for salt-induced precipitation of proteins.
The study of the solubility behavior of amino acids and proteins in aqueous electrolyte solutions is of utmost importance to understand the biochemistry of natural systems, develop medical and pharmaceutical responses to diseases induced by biochemical disorders and improve the efficiency of biotechnological processes. Although the effect of common salts on the aqueous solubility of amino acids and proteins is ...
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