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The cation effect on the aqueous solubility of amino acids in the presence of s...

Aiming at contributing to the understanding the molecular level mechanisms governing the behavior of biocompounds in aqueous saline environments, experimental solubility measurements and molecular dynamics (MD) simulations were performed for aqueous solutions of three amino acids (alanine, valine and isoleucine) in the presence of a series of inorganic salts.

Experimental and molecular dynamics simulation studies on thee solubilityof ami...

Separation and concentration of biological compounds are current subjects of interest due to their high cost in comparison to the total manufacture cost. For that purpose electrolytes may be employed as they can effect significantly biochemicals solubilities, a feature that has been used for salt-induced precipitation of proteins.

The cation effect on the aqueous solubility of amino acids in the presence of s...

The study of the solubility behavior of amino acids and proteins in aqueous electrolyte solutions is of utmost importance to understand the biochemistry of natural systems, develop medical and pharmaceutical responses to diseases induced by biochemical disorders and improve the efficiency of biotechnological processes. Although the effect of common salts on the aqueous solubility of amino acids and proteins is ...

Gastric splenosis: a rare cause of digestive bleeding

Metastização Cólica: Uma forma rara de apresentação do carcinoma gástrico

O carcinoma gástrico é uma neoplasia com distribuição mundial, estando as fases avançadas da doença associadas à metastização à distância para múltiplos órgãos. Contudo, as metástases para o cólon são raras e habitualmente surgem como recidiva da doença, geralmente nos primeiros 5 anos após o diagnóstico. Os autores apresentam o caso clínico de um doente do sexo masculino, 69 anos de idade, com um quadro clínic...

Bezoar gástrico e intestinal: caso clínico e revisão da literatura

Os bezoars gastrointestinais são achados relativamente raros, apresentando uma variação regional na sua distribuição relacionada com diferenças na ingestão de alimentos ricos em fibras. A sua verdadeira incidência é desconhecida. A sua ocorrência apresenta uma tendência crescente, em provável relação com a maior taxa de cirurgias gastroduodenais realizadas no último século, consideradas factores de risco para a...

Double pylorus with bleeding gastric ulcer - a rare event

Deposition and passage of transthyretin through the blood-nerve barrier in reci...

Familial amyloid polyneuropathy (FAP) is characterized by deposition of mutated transthyretin (TTR) in the peripheral nervous system. Prior to amyloid fibrils, nonfibrillar TTR aggregates are deposited inducing oxidative stress with increased nitration (3-NT). As the major source of TTR is the liver, liver transplantation (LT) is used to halt FAP. Given the shortage of liver donors, domino LT (DLT) using FAP li...

The Coimbra University Hospital experience in liver transplantation in patients...

One year of Lamivudine therapy for portuguese patients with chronic hepatitis B.

OBJECTIVE: To further verify the efficacy and safety of locally manufactured lamivudine on patients with chronic hepatitis B (CHB). METHODS: 2200 patients with CHB were recruited and received lamivudine orally 100 mg once daily for 12 months. The efficacy assessments included virologic response rate (defined by the absence of serum HBV DNA, HBeAg loss and HBeAg/HBeAb seroconversion), percentage of patients wit...