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Strategies to enhance the removal of Fluoroquinolones
Amorim, Catarina L.; Maia, Alexandra S.; Moreira, Irina S.; van Loosdrecht, Mark C.M.; Tiritan, Maria E.; Castro, Paula M.L.Fluoroquinolones (FQs) are broad-spectrum antibiotics that play an important role in the treatment of serious bacterial infections. Currently, several FQs are available but ciprofloxacin (CPF), ofloxacin (OFL) and norfloxacin (NOR) are amongst the most worldwide prescribed antibiotics. Antibiotics can reach wastewater treatment plants (WWTP) from different routes. Thus removal of these contaminants during the b...
Studies on enantioselective biodegradation of fluoxetine
Moreira, Irina S.; Ribeiro, Ana R.; Amorim, Catarina L.; Tiritan, Maria E.; Castro, Paula M. L.Fluoxetine (FLX) is a chiral fluorinated pharmaceutical indicated mainly for treatment of depression and is one of the most dispensed drugs in the world. There is a clear evidence of environmental contamination with this drug. Granular sludge sequencing batch reactors (SBR) constitute a promising technology for the treatment of effluents containing micropollutants. In this study, a SBR was operated in order to...
Pharmaceuticals biodegradation by activated sludge and pure cultures
Bessa, Vânia S.; Moreira, Irina S.; Maia, Alexandra S.; Tiritan, Maria E.; Castro, Paula M. L.The occurrence of pharmaceuticals in the environment have been a topic of increasing concern. Most of the pharmaceuticals are not completely mineralized in the human body and are released on the sewage systems as the pharmaceutical itself and as their “biologically active” metabolites through excretion, as well as by improper elimination and disposal. Once current wastewater treatment plants (WWTPs) are not des...
Enantioselective Degradation of Enantiomers of Fluoxetine Followed by HPLC- FD
Ribeiro, Ana R.; Maia, Alexandra S.; Moreira, Irina S.; Afonso, Carlos; Castro, Paula M.L.; Tiritan, Maria E.Environmental fate assessment of chiral pharmaceuticals is an important issue and little information is known about enantioselectivity in the environment. This kind of information is important for regulamentation of pharmaceutical industry and chiral switching processes. Fluoxetine (FLX), an anti-depressant worldwide used, is a chiral pharmaceutical prescribed in racemic form, and its main metabolite norfl...
Enantioselective Determination of Fluoxetine and Norfluoxetine in Wastewater
Ribeiro, Ana R.; Maia, Alexandra S.; Moreira, Irina S.; Afonso, Carlos; Castro, Paula M.L.; Tiritan, Maria E.Microbial degradation of chiral compounds during wastewater treatment processes can be enantioselective and needs chiral analytical methodology to discriminate the biodegradation of both enantiomers. An enantioselective HPLC-FD method was developed and validated to monitor the degradation of fluoxetine (FLX) enantiomers by wastewater and the possible formation of its metabolite norfluoxetine (NFLX). The So...
Degradation of Fluoroquinolone Antibiotics and Identification of Metabolites/Tr...
Maia, Alexandra S.; Ribeiro, Ana R.; Amorim, Catarina L.; Barreiro, Juliana C.; Cass, Quezia B.; Castro, Paula M.L.; Tiritan, Maria E.Antibiotics are a therapeutic class widely found inenvironmental matrices and extensively studied due to its persistence and implications for multi-resistant bacteria development. Degradation of four fluoroquinolone antibiotics, namely Ofloxacin (OFL), Norfloxacin (NOR), Ciprofloxacin (CPF) and Moxifloxacin (MOX), at 10 mg L-1 using a mixed bacterial culture, was assessed for 60 days. The assays were follow...
Solid Phase Extraction of Fluoroquinolone Antibiotics from Wastewaters – Assess...
Maia, Alexandra S.; Ribeiro, Ana R.; Castro, Paula M.L.; Tiritan, Maria E.Microbial degradation of fluorinated pharmaceuticalsduring wastewater treatment processes remains inadequate in most situations. Due to incomplete elimination, these residues are continually being introduced into the aquatic environments in which they settle throughout time since many of them are resistant to degradation. Fluoroquinolone antibiotics due to its persistence and implication on resistant-bacteria ...
Development and Optimization of an Online SPE-HPLC-FD Method for Quantification...
Meira, Bernardo; Maia, Alexandra S.; Gonçalves, Virgínia M. F.; Ribeiro, Ana R.; Tiritan, Maria E.Fluoroquinolones are antimicrobial agents widely found in environmental matrices and extensively studied due to their persistence and implications for multiresistant bacteria. The presence of fluoroquinolones in the environment is mainly due to the incapability of wastewater treatment plants (WWTPs) to completely remove those compounds. The amount of fluoroquinolones released through effluents depends on the ty...
Aerobic granules in a sequencing batch bioreactor under fluoroquinolone shock l...
Amorim, Catarina L.; Maia, Alexandra S.; Mesquita, Raquel B. R.; Rangel, António O. S. S.; Tiritan, Maria E.; Castro, Paula M. L.The growing occurrence of human and veterinary pharmaceuticals in the environment is causing increasing concern. Fluoroquinolones (FQs) are broad-spectrum antibiotics that play an important role in the treatment of serious bacterial infections. Antibiotics can reach wastewater treatment plants (WWTP) from different routes. Domestic effluents are considered the major contributor but effluents from pharmaceutical...
Effects of fluoxetine schock loadings in a aerobic granular sludge sequencing b...
Moreira, Irina S.; Ribeiro, Ana R.; Amorim, Catarina L.; Mesquita, Raquel B. R.; Rangel, António O. S. S.; Tiritan, Maria E.; Castro, Paula M. L.Pharmaceuticals have received increasing attention as emerging organic pollutants due to their frequent occurrence in the environment and potential adverse effects on ecossistems and to human health. Pharmaceuticals may not be completely metabolized in the human body and can enter municipal sewage systems as the parent drug and as their “biologically active” metabolites. Some of these compounds cannot be easily...
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