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Growth cartilage expression of growth hormone/insulin-like growth factor I axis...
Brito, I; Gil-Peña, H; Molinos, I; Loredo, V; Tiago Henriques-Coelho; Caldas-Afonso, A; Santos, FINTRODUCTION: Catch-up growth following the cessation of a growth inhibiting cause occurs in humans and animals. Although its underlying regulatory mechanisms are not well understood, current hypothesis confer an increasing importance to local factors intrinsic to the long bones' growth plate (GP). AIM: The present study was designed to analyze the growth-hormone (GH)-insulin-like growth factor I (IGF-I) axis i...
Time course and mechanisms of left ventricular systolic and diastolic dysfuncti...
Correia-Pinto, J; Tiago Henriques-Coelho; Roncon-Albuquerque R, Jr.; Lourenço, AP; Melo-Rocha, G; Vasques-Nóvoa, F; Gillbert, TCAlthough pulmonary hypertension (PH) selectively overloads the right ventricle (RV), neuroendocrine activation and intrinsic myocardial dysfunction have been described in the left ventricle (LV). In order to establish the timing of LV dysfunction development in PH and to clarify underlying molecular changes, Wistar rats were studied 4 and 6 weeks after subcutaneous injection of monocrotaline (MCT) 60 mg/kg (MCT...
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