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A study on the immune response elicited in mice challenged with Staphylococcus ...
Cerca, Filipe; Teixeira, Luzia; Cerca, Nuno; Madureira, Pedro; Ribeiro, Adília; Azeredo, Joana; Vilanova, ManuelIn this study a biofilm-forming strain of Staphylococcus epidermidis was used in order to evaluate, in a murine model, the immune response to bacteria grown either as planktonic cells or biofilm. Groups of male BALB/c mice were infected intra-peritoneally (i.p.), with 2×10^8 S. epidermidis cells per mice, obtained either from a mature biofilm (grown for 48h) or from a planktonic cell culture. Mice were sacrific...
Protection against systemic candidiasis in mice immunized with secreted asparti...
Vilanova, Manuel; Teixeira, Luzia; Caramalho, Íris; Torrado, Egídio; Marques, Andreia; Madureira, Pedro; Ribeiro, Adília; Ferreira, Paula; Gama, F. M.Secreted aspartic proteinases (Sap) have been described as virulence factors implicated in the mechanisms of host colonization by the yeast Candida albicans in different types of candidiasis. Intraperitoneal inoculation of C. albicans into BALB/c mice rapidly leads to systemic candidiasis, with significant colonization of the kidneys measurable in the following week. In this study we assessed the potential of v...
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