Encontrados 2 documentos, a visualizar página 1 de 1
Self-assembled mannan nanogel : cytocompatibility and cell localization
Ferreira, Sílvia A.; Carvalho, Vera; Vilanova, Manuel; Costa, Carla Isabel; Teixeira, João P.; Gama, F. M.Amphiphilic mannan, produced by the Michael addition of hydrophobic 1-hexadecanethiol to vinyl methacrylated mannan, self-assembles in aqueous medium through hydrophobic interactions among alkyl chains. Resultant nanogel is stable, spherical, polydisperse, with 50–140 nm mean hydrodynamic diameter depending on the polymer degree of substitution, and nearly neutral negative surface charge. No cytotoxicity of man...
Self-assembled dextrin nanogel as protein carrier : controlled release and biol...
Carvalho, Vera; Castanheira, Pedro; Madureira, Pedro; Ferreira, Sílvia A.; Costa, Carlos M.; Faro, Carlos; Teixeira, João P.; Vilanova, ManuelInterleukin-10 (IL-10) is an anti-inflammatory cytokine, which active form is a non-covalent homodimer. Given the potential of IL-10 for application in various medical conditions, it is essential to develop systems for its effective delivery. In previous work, it has been shown that a dextrin nanogel effectively incorporated and stabilized rIL10, enabling its release over time. In this work, the delivery system...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||