Encontrados 6 documentos, a visualizar página 1 de 1
Benefits of spine stabilization with biodegradable scaffolds in spinal cord inj...
Silva, Nuno; Sousa, R. A.; Fraga, J. S.; Fontes, Marco; Almeida, Hugo Leite; Cerqueira, R.; Almeida, Armando; Sousa, Nuno; Reis, R. L.; Salgado, A. J.Spine stabilization upon spinal cord injury (SCI) is a standard procedure in clinical practice, but rarely employed in experimental models. Moreover, the application of biodegradable biomaterials for this would come as an advantage as it would eliminate the presence of a nondegradable prosthesis within the vertebral bone. Therefore, in the present work, we propose the use of a new biodegradable device specifica...
Development and characterization of PHB-HV based 3D scaffolds for a tissue engi...
Samy, S. M.; Silva, Nuno; Pinto, Luísa; Castro, Andreia Cristiana Teixeira de; Almeida, Hugo Leite; Almeida, Armando; Sousa, Nuno; Salgado, António J.Spinal cord injury (SCI) leads to devastating neurological deficits. Several tissue engineering (TE)- based approaches have been investigated for repairing this condition. Poly (3-hydroxybutyrateco- 3-hydroxyvalerate) (PHB-HV) is found to be particularly attractive for TE applications due to its properties, such as biodegradability, biocompatibility, thermoplasticity and piezoelectricity. Hence, this report add...
Variable delay-to-signal : a fast paradigm for assessment of aspects of impulsi...
Almeida, Hugo Leite; Melo, António; Pêgo, José M.; Bernardo, Sara; Milhazes, Nuno; Borges, Fernanda; Sousa, Nuno; Almeida, Armando; Cerqueira, JoãoTesting impulsive behavior in rodents is challenging and labor-intensive. We developed a new behavioral paradigm-the Variable Delay-to-Signal (VDS) test-that provides rapid and simultaneous assessment of response and decision impulsivity in rodents. Presentation of a light at variable delays signals the permission for action (nose poke) contingent with a reward. 2 blocks of 25 trials at 3 s delay flank a block ...
Development and characterization of a novel hybrid tissue engineering-based sca...
Silva, Nuno; Salgado, A. J.; Sousa, R. A.; Oliveira, João T.; Pedro, A. J.; Almeida, Hugo Leite; Cerqueira, R.; Almeida, Armando; Mastronardi, F.Spinal cord injury (SCI) represents a significant health and social problem, and therefore it is vital to develop novel strategies that can specifically target it. In this context, the objective of the present work was to develop a new range of three-dimensional (3D) tubular structures aimed at inducing the regeneration within SCI sites. Up to six different 3D tubular structures were initially developed by rapi...
Brain projections from the medullary dorsal reticular nucleus : an anterograde ...
Almeida, Hugo Leite; Fernandes, Ana Valle; Almeida, ArmandoIn the last 15 years a role has been ascribed for the medullary dorsal reticular nucleus as a supraspinal pain modulating area. The medullary dorsal reticular nucleus is reciprocally connected with the spinal dorsal horn, is populated mainly by nociceptive neurons and regulates spinal nociceptive processing. Here we analyze the distribution of brain projections from the medullary dorsal reticular nucleus using ...
Medullary control of nociceptive transmission : reciprocal dual communication w...
Almeida, Armando; Almeida, Hugo Leite; Tavares, IsauraControl of pain perception, essential for organism surviving and recovery from disease, is exerted by higher brain centers integrating nociception with emotional and cognitive information and modulating the brainstem-spinal feedback loops that regulate spinal nociceptive transmission. Development of chronic pain deregulates the forebrain-brainstem-spinal pain control system, which leads to neuroplasticity and d...
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