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Neurological involvement in Primary Sjögren’s Syndrome

Sitagliptin treatment prevented pancreatic lesions evolution in a rat modelo f ...

Background: This study aimed to elucidate mechanisms underlying the protective effects of sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, against pancreatic lesions, in an animal model of T2DM. Methods: Male obese diabetic ZDF (fa/fa) rats, 20-weeks-old, were treated with vehicle or sitagliptin (10mg/kg BW/day) for 6 weeks, and compared with lean control littermates (n=8/each). Biochemical parameters ...

Controlo microbiológico de formulações farmacêuticas parentéricas

O controlo microbiológico de formulações injectáveis visa garantir a isenção de um produto farmacêutico em termos microrganismos, possivelmente patogénicos, que possam induzir sintomas patológicos após a sua administração. Assim, o estudo das técnicas que permitam a eliminação de agentes patogénicos e a sua prevenção é de extrema importância. Nesta área são utilizadas diversas técnicas clássicas para avaliar de...

Mesenchymal stem cells secretome : a new paradigm for Central Nervous System Re...

The low regeneration potential of the central nervous system (CNS) represents a challenge for the development of new therapeutic strategies. Mesenchymal stem cells (MSCs) have been proposed as a possible therapeutic tool for CNS disorders. In addition to their differentiation potential, it is well accepted nowadays that their beneficial actions can also be mediated by their secretome. Indeed, it was already dem...

Mesenchymal stem cells secretome : a new paradigm for central nervous system re...

The low regeneration potential of the central nervous system (CNS) represents a challenge for the development of new therapeutic strategies. Mesenchymal stem cells (MSCs) have been proposed as a possible therapeutic tool for CNS disorders. In addition to their differentiation potential, it is well accepted nowadays that their beneficial actions can also be mediated by their secretome. Indeed, it was already dem...

Chemopreventive Efficacy of Atorvastatin against Nitrosamine-Induced Rat Bladde...

To investigate the anti-carcinogenic effects of Atorvastatin (Atorva) on a rat bladder carcinogenesis model with N-butyl-N-(4-hydroxibutil)nitrosamine (BBN), four male Wistar rat groups were studied: (1) Control: vehicle; (2) Atorva: 3 mg/kg bw/day; (3) Carcinogen: BBN (0.05%); (4) Preventive Atorva: 3 mg/kg bw/day Atorva + BBN. A two phase protocol was used, in which the drug and the carcinogen were given betw...

Sitagliptin delays progression of renal lesions in a rodent model of type 2 dia...

Avaliação da Actividade Microbiana de Bisfosfonatos Derivados do Indazole

Os bisfosfonatos (BPs) são um grupo de compostos derivados do ácido bisfosfónico e dos seus sais. Os bisfosfonatos (BPs) são uma classe importante de fármacos com um largo espectro de aplicações no tratamento de doenças do metabolismo mineral do osso, como a osteoporose, a doença de Paget e metástases ósseas, com uma acção inibidora sobre os osteoclastos, promovendo uma diminuição da reabsorção óssea. Recenteme...

Bisfosfonatos Derivados do Indazole: Síntese e Avaliação da Actividade Microbiana

Os bisfosfonatos (BPs) são um grupo de compostos derivados do ácido bisfosfónico e dos seus sais, onde o oxigénio do grupo P-O-P foi substituído por um átomo de carbono, resultando na estrutura P-C-P, metabolicamente mais estável. Estes compostos constituem uma classe importante de fármacos, com um largo espectro de aplicações no tratamento de doenças do metabolismo mineral do osso, como a osteoporose, a doença...

Pancreatic lesions and metabolic aggravation are prevented by low doses of sita...

Introduction: The management of type 2 diabetes is designed to reduce disease-related complications and improve long-term outcomes. Inhibition of dipeptidyl peptidase-4 (DPP-4) activity by sitagliptin has been shown to improve glycaemic control in patients with type 2 diabetes Mellitus (T2DM) by prolonging the actions of incretin hormones, but the real impact of low-dose sitagliptin treatment on cardiometabolic...