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Sustained oxidative stress inhibits NF-[kappa]B activation partially via inacti...
Wu, Mingxing; Bian, Qingning; Liu, Yizhi; Fernandes, Alexandre F.; Taylor, Allen; Pereira, Paulo; Shang, Fuhttp://www.sciencedirect.com/science/article/B6T38-4TK92CN-1/2/ef8f7b10021e625df74be4471bbf0552
Proteasome-dependent regulation of signal transduction in retinal pigment epith...
Fernandes, Alexandre F.; Guo, Weimin; Zhang, Xinyu; Gallagher, Matthew; Ivan, Mircea; Taylor, Allen; Pereira, Paulo; Shang, FuAs in many other types of cells, retinal pigment epithelial (RPE) cells have an active ubiquitin-proteasome pathway (UPP). However, the function of the UPP in RPE remains to be elucidated. The objective of this study is to determine the role of the UPP in controlling the levels and activities of transcription factors hypoxia-inducible factor (HIF) and NF-[kappa]B. We inhibited the UPP with proteasome-specific i...
Subcellular redistribution of components of the ubiquitin-proteasome pathway du...
Girão, Henrique; Pereira, Paulo; Taylor, Allen; Shang, FuPURPOSE: To determine the subcellular distribution of components of the ubiquitin-proteasome pathway (UPP) in lens epithelium and differentiating fibers and to evaluate potential roles of the UPP in eliminating nuclei and other organelles during maturation of lens fibers. METHODS: Adult bovine lens cryosections were stained for immunofluorescence and analyzed by confocal microscopy. The specificities of the ant...
Lens fibers have a fully functional ubiquitin-proteasome pathway
Pereira, Paulo; Shang, Fu; Hobbs, Marisa; Girão, Henrique; Taylor, AllenWe previously showed that lens epithelial cells have a fully functional ubiquitin-proteasome pathway (UPP) and that ubiquitin-conjugating activity is up-regulated in response to oxidative stress. In this study we assessed the protein levels and activities of different components of the UPP in lens fibers. Calf lenses were dissected into four different regions: epithelial layer, outer cortex, inner cortex and nu...
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