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Digit Ratio (2D:4D) in Newborns: Influences of Prenatal Testosterone and Matern...
Ventura, T; Gomes, MC; Pita, A; Neto, MT; Taylor, AIntroduction: The 2D:4D digit ratio is sexually-dimorphic, probably due to testosterone action through the perinatal period. We characterize the 2D:4D ratio in newborn (NB) infants, in between the pre- and postnatal surges of testosterone, and relate it to the mother's 2D:4D and to testosterone levels in the amniotic fluid (AF). Subjects and methods: Testosterone was assayed in samples of maternal plasma and AF...
Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranyl...
Baron, RA.; Tavare, R.; Figueiredo, AC.; Blazewska, KM.; Kashemirov, BA.; McKenna, CE.; Ebetino, FH.; Taylor, A.; Rogers, MJ.; Coxon, FP.; Seabra, MC.Rab geranylgeranyl transferase (RGGT) catalyzes the post-translational geranylgeranyl (GG) modification of (usually) two C-terminal cysteines in Rab GTPases. Here we studied the mechanism of the Rab geranylgeranylation reaction by bisphosphonate analogs in which one phosphonate group is replaced by a carboxylate (phosphonocarboxylate, PC). The phosphonocarboxylates used were 3-PEHPC, which was previously report...
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