Encontrados 3 documentos, a visualizar página 1 de 1
The expression of tubulin cofactor A (TBCA) is regulated by a noncoding antisen...
Nolasco, Sofia; Bellido, Javier; Gonçalves, João; Zabala, Juan Carlos; Soares, Helena; Tavares, AlexandraAbstract - Recently, long noncoding RNAs have emerged as pivotal molecules for the regulation of coding genes' expression. These molecules might result from antisense transcription of functional genes originating natural antisense transcripts (NATs) or from transcriptional active pseudogenes. TBCA interacts with β-tubulin and is involved in the folding and dimerization of new tubulin heterodimers, the building ...
Mob1: defining cell polarity for proper cell division
Tavares, Alexandra; Gonçalves, João; Florindo, Cláudia; Tavares, Álvaro A.; Soares, HelenaMob1 is a component of both the mitotic exit network and Hippo pathway, being required for cytokinesis, control of cell proliferation and apoptosis. Cell division accuracy is crucial in maintaining cell ploidy and genomic stability and relies on the correct establishment of the cell division axis, which is under the control of the cell's environment and its intrinsic polarity. The ciliate Tetrahymena thermophil...
CCTα and CCTδ chaperonin subunits are essential and required for cilia assembly...
Seixas, Cecília; Cruto, Teresa; Tavares, Alexandra; Gaertig, Jacek; Soares, HelenaBackground - The eukaryotic cytosolic chaperonin CCT is a hetero-oligomeric complex formed by two rings connected back-to-back, each composed of eight distinct subunits (CCTalpha to CCTzeta). CCT complex mediates the folding, of a wide range of newly synthesised proteins including tubulin (alpha, beta and gamma) and actin, as quantitatively major substrates. Methodology/Principal findings - We disrupted the gen...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||