Encontrados 12 documentos, a visualizar página 1 de 2
Estudo piloto para o rastreio neonatal da fibrose quística
Lopes, Lurdes; Marcão, Ana; Carvalho, Ivone; Sousa, Carmen; Fonseca, Helena; Rocha, Hugo; Vilarinho, LauraO Programa Nacional de Diagnóstico Precoce (PNDP) realiza-se em Portugal desde 1979, e atualmente inclui o rastreio neonatal de 24 Doenças Hereditárias do Metabolismo (DHM) e do Hipotiroidismo Congénito (HC). Em Outubro de 2013 iniciou-se, um estudo piloto para o rastreio neonatal da Fibrose Quística (FQ), que deverá ser efetuado em 80000 recém-nascidos (RN) portugueses ao longo de aproximadamente um ano. A Fib...
Novas Tecnologias da Informação e Comunicação e a construção do conhecimento : ...
Carvalho, Ivone Soares Leandro deA sociedade moderna atual aponta para a necessidade de ajustar a educação ao novo cenário social que se configura. Com o advento tecnológico cada vez mais coevo e necessário é significante somar esforços para ampliar e validar as discussões sobre as Novas Tecnologias da Informação e Comunicação (NTIC), com mais expressividade a Internet, como um dos elementos potencializador do processo de construção do conheci...
Programa Nacional de Diagnóstico Precoce em Portugal- Casuística de 2011
Lopes, Lurdes; Sousa, Carmen; Fonseca, Helena; Carvalho, Ivone; Marcão, Ana; Rocha, Hugo; Vilarinho, LauraO Programa Nacional de Diagnóstico Precoce (PNDP) visa identificar doenças nas primeiras semanas de vida do bebé de forma a possibilitar uma intervenção precoce e a impedir a ocorrência de atraso mental, doença grave irreversível ou morte da criança. O PNDP iniciou-se em 1979 com o rastreio da fenilcetonúria tendo-se implementado em 1981 o rastreio do hipotiroidismo congénito. As novas tecnologias de espectrom...
Biotransformation of a tetrahydrofuran lignan by the endophytic fungus Phomopsi...
Verza,Michelle; Arakawa,Nilton S.; Lopes,Norberto P.; Kato,Massuo J.; Pupo,Mônica T.; Said,Suraia; Carvalho,IvoneThe biotrasformation of the tetrahydrofuran lignan, (-)-grandisin, by the endophitic fungus Phomopsis sp, obtained from Viguiera arenaria, led to the formation of a new compound determined as 3,4-dimethyl-2-(4'-hydroxy-3',5'-dimethoxyphenyl)-5-methoxy-tetrahydrofuran. The metabolite was evaluated against the parasite Trypanosoma cruzi, the causative agent of Chagas's disease, and showed a trypanocidal activity ...
Síntese de glicoaminoácidos de interesse biológico
Campo,Vanessa Leiria; Carvalho,IvoneThis work describes the synthesis of the glycosylated amino acids αGlcNAc-Thr, βGlcNAc-Thr and αLacNAc-Thr by the glycosylation reaction of the amino acid threonine with the corresponding glycosyl donors αGlcNAcCl and αLacN3Cl. The glycosylated amino acids containing the sugar units α-D-GlcNAc and α-D-LacNAc O-linked to threonine amino acids are related to O-glycans found in m...
Estatinas hipolipêmicas e novas tendências terapêuticas
Campo,Vanessa Leiria; Carvalho,IvoneStatins are the most used drugs for the treatment of hyperlipidemia in primary and secondary prevention, with the aim of decreasing the levels of plasmatic cholesterol- lipoproteins. Owing to their structural similarity to the substrate HMG-CoA (3-hydroxy-3-methylglutaryl-CoA), they inhibit the HMG-CoA reductase enzyme, disrupting the cholesterol biosynthesis. Currently, six therapeutic statins are available: l...
alfa e b-glucosidases como alvos moleculares para desenvolvimento de fármacos
Melo,Eduardo Borges de; Carvalho,IvoneGlucosidases are involved in key steps in the processing of oligosaccharides by cleaving O-glucose residues. Since they catalyze breaking and transfer reactions of glucosidic groups for the normal growth and development of all the cells, defects or genetic deficiencies in these enzymes are associated with serious disorders of the carbohydrate metabolism. Thus, glucosidases represent important targets to develop...
HPLC analysis of glycosylated amino acids
Campo,Vanessa L.; Borges,Áurea D. L.; Carvalho,IvoneThis work describes the standardization of HPLC analysis methodology for the identification and separation of the glycosylated amino acids (building blocks) 3, 4, 7 and 8 and their respective precursors. The glycosylated amino acids containing the sugar units beta-D-GlcNAc (3 and 7) O-linked to threonine amino acids are involved in cellular signalling events, and the correspondent isomers 4 and 8, possessing al...
Síntese de sulfadiazina e sulfadiazina de prata em escala semi-micro: prática e...
Borges,Áurea Donizete Lanchote; Ponte,Gino Del; Federman Neto,Alberto; Carvalho,IvoneThe total synthesis of sulfadiazine and silver sulfadiazine from readily available starting materials was adapted to semi-micro laboratory scale and is proposed as an experiment in drug synthesis for undergraduate courses.
Diketopiperazines produced by an Aspergillus fumigatus Brazilian strain
Furtado,Niege A. J. C.; Pupo,Mônica T.; Carvalho,Ivone; Campo,Vanessa L.; Duarte,Marta Cristina T.; Bastos,Jairo K.Seven diketopiperazines, corresponding to the cyclos (L)-Pro-(L)-Phe, (L)-Pro-Gly, (L)-Pro-(L)-Pro, (L)-Pro-(L)-Val, (L)-4-OH-Pro-(L)-Leu, (L)-4-OH-Pro-(L)-Phe, and (L)-Pro-(L)-Leu, were isolated from the Aspergillus fumigatus fermentation broth. The relative and absolute stereochemistries were determined on the basis of NOESY experiments and by using a modified version of Marfey's method using HPLC, respectively.
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