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Mitochondria dysfunction of Alzheimer's disease cybrids enhances Aβ toxicity
Cardoso, Sandra M.; Santana, Isabel; Swerdlow, Russell H.; Oliveira, Catarina R.Alzheimer's disease (AD) brain reveals high rates of oxygen consumption and oxidative stress, altered antioxidant defences, increased oxidized polyunsaturated fatty acids, and elevated transition metal ions. Mitochondrial dysfunction in AD is perhaps relevant to these observations, as such may contribute to neurodegenerative cell death through the formation of reactive oxygen species (ROS) and the release of mo...
Functional mitochondria are required for amyloid beta-mediated neurotoxicity
Cardoso, Sandra Morais; Santos, Sancha; Swerdlow, Russell H.; Oliveira, Catarina R.The role of mitochondria in amyloid bpeptide (Ab)-induced cytotoxicity is unclear. We therefore exposed NT2 cells, a clonal human teratocarcinoma cell line capable of differentiation into terminal neurons, to Ab 25-35 or to Ab 1-42 to evaluate cell viability and altered mitochondrial function. A 24-h incubation of native NT2 cells (r+ cells) with Ab 25-35 or with Ab 1-42 produced a dose-dependent decline in MTT...
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