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TLR9 activation dampens the early inflammatory response to paracoccidioides bra...
Menino, João F.; Saraiva, Margarida; Alves, Ana G. Gomes; Silva, Diogo; Sturme, Mark H. J.; Gomes, Jéssica Angélica Rezende; Pedrosa, JorgeBackground: Paracoccidioides brasiliensis causes paracoccidioidomycosis, one of the most prevalent systemic mycosis in Latin America. Thus, understanding the characteristics of the protective immune response to P. brasiliensis is of interest, as it may reveal targets for disease control. The initiation of the immune response relies on the activation of pattern recognition receptors, among which are TLRs. Both T...
P. brasiliensis virulence is affected by SconC, the negative regulator of inorg...
Menino, João F.; Saraiva, Margarida; Gomes, Jéssica Angélica Rezende; Sturme, Mark H. J.; Pedrosa, Jorge; Castro, António G.; Ludovico, PaulaConidia/mycelium-to-yeast transition of Paracoccidioidesbrasiliensis is a critical step for the establishment of paracoccidioidomycosis, a systemic mycosis endemic in Latin America. Thus, knowledge of the factors that mediate this transition is of major importance for the design of intervention strategies. So far, the only known pre-requisites for the accomplishment of the morphological transition are the tempe...
Functionality of the paracoccidioides mating α-pheromone-receptor system
Gomes, Jéssica Angélica Rezende; Alves, Ana G. Gomes; Menino, João F.; Coelho, Marco; Ludovico, Paula; Gonçalves, Paula; Sturme, Mark H. J.Recent evidence suggests that Paracoccidioides species have the potential to undergo sexual reproduction, although no sexual cycle has been identified either in nature or under laboratory conditions. In the present work we detected low expression levels of the heterothallic MAT loci genes MAT1-1 and MAT1-2, the a-pheromone (PBa) gene, and the a- and apheromone receptor (PREB and PREA) genes in yeast and mycelia...
Effect of Lactobacillus salivarius bacteriocin Abp118 on the mouse and pig inte...
Riboulet-Bisson, Eliette; Sturme, Mark H. J.; Jeffery, Ian B; O'Donnell, Michelle M; Neville, Anne; Forde, Brian M; Claesson, Marcus J; Harris, HughLactobacilli are gram-positive bacteria that are a subdominant element in the human gastrointestinal microbiota, and which are commonly used in the food industry. Some lactobacilli are considered probiotic, and have been associated with health benefits. However, there is very little culture-independent information on how consumed probiotic microorganisms might affect the entire intestinal microbiota. We therefo...
Molecular biology of the dimorphic fungi Paracoccidioides SPP
Sturme, Mark H. J.; Puccia, Rosana; Goldman, Gustavo H.; Rodrigues, Fernando José dos SantosParacoccidioides spp, herein commonly referred as Paracoccidioides brasiliensis, is the etiological agent of racoccidioidomycosis (PCM), the most prevalent systemic mycosis endemic in Latin America. Many aspects of the biology of P. brasiliensis remain unknown, in particular its ecology and the apparent lack of a sexual reproduction stage in its life cycle. This review will highlight the current knowledge on t...
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