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Effects of testosterone, 17beta-estradiol, and downstream estrogens on cytokine...
Janele, D; Lang, T; Capellino, S; Cutolo, M; Pereira da Silva, JA; Straub, RHEstrogens at physiological concentrations are thought to play an immune-stimulating role, whereas androgens have an anti-inflammatory impact. However, their role on cytokine secretion in the presence or absence of cortisol has not been investigated. Furthermore, the role of hydroxylated estrogens downstream of 17beta-estradiol (E2) on secretion of tumor necrosis factor (TNF) is not known. In this study on perip...
Differential male and female adrenal cortical steroid hormone and cortisol resp...
Silva, C; Inês, L; Nour, D; Straub, RH; Pereira da Silva, JAEvidence from experimental animal studies show that sex hormones influence the glucocorticoid response to a variety of inflammatory and noninflammatory stimuli. In this study we assessed gender differences in the response of ACTH and cortisol in normal young male and female humans following intravenous infusion of human IL-6 in various dosages. Males presented a significantly stronger ACTH production in respons...
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