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Identification of Li+ binding sites and the effect of Li+ treatment on phosphol...
Layden, Brian T.; Abukhdeir, Abde M.; Malarkey, Christopher; Oriti, Lisa A.; Salah, Wajeeh; Stigler, Claire; Geraldes, Carlos F. G. C.Li+ binding in subcellular fractions of human neuroblastoma SH-SY5Y cells was investigated using 7Li NMR spin-lattice (T1) and spin-spin (T2) relaxation measurements, as the T1/T2 ratio is a sensitive parameter of Li+ binding. The majority of Li+ binding occurred in the plasma membrane, microsomes, and nuclear membrane fractions as demonstrated by the Li+ binding constants and the values of the T1/T2 ratios, wh...
Data: 2005
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Origem: Estudo Geral - Universidade de Coimbra
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