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Tauroursodeoxycholic acid prevents Bax-induced membrane perturbation and cytoch...
Rodrigues, Cecília M. P.; Solá, Susana; Sharpe, Juanita C.; Moura, José J. G.; Steer, Clifford J.Biochemistry, 2003, 42 (10), pp 3070–3080 DOI: 10.1021/bi026979d ; Bax is a potent pro-apoptotic member of the Bcl-2 protein family that localizes to the mitochondrial membrane during apoptosis. Tauroursodeoxycholic acid (TUDCA) modulates the apoptotic threshold, in part, by preventing Bax translocation both in vitro and in vivo. The mechanisms by which Bax induces and TUDCA inhibits release of cytochrome c ar...
Data: 2003
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Origem: Repositório Institucional da UNL
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