Encontrados 3 documentos, a visualizar página 1 de 1
Competition between lithium and magnesium ions for the G-protein transducin in ...
Srinivasan, Chandra; Toon, Jason; Amari, Louis; Abukhdeir, Abde M.; Hamm, Heidi; Geraldes, Carlos F. G. C.; Ho, Yee-Kin; Freitas, Duarte Mota deLi+ is the most effective drug used to treat bipolar disorder; however, its exact mechanism of action has yet to be elucidated. One hypothesis is that Li+ competes with Mg2+ for the Mg2+ binding sites on guanine-nucleotide binding proteins (G-proteins). Using 7Li T1 relaxation measurements and fluorescence spectroscopy with the Mg2+ fluorophore furaptra, we detected Li+/Mg2+ competition in three preparations: t...
Competition between Na+ and Li+ for Unsealed and Cytoskeleton-Depleted Human Re...
Srinivasan, Chandra; Minadeo, Nicole; Toon, Jason; Graham, Daniel; Freitas, Duarte Mota de; Geraldes, Carlos F. G. C.Evidence for competition between Li+ and Na+ for binding sites of human unsealed and cytoskeleton-depleted human red blood cell (csdRBC) membranes was obtained from the effect of added Li+ upon the 23Na double quantum filtered (DQF) and triple quantum filtered (TQF) NMR signals of Na+-containing red blood cell (RBC) membrane suspensions. We found that, at low ionic strength, the observed quenching effect of Li+...
Competition between Li+ and Mg2+ for red blood cell membrane phospholipids: A 3...
Srinivasan, Chandra; Minadeo, Nicole; Geraldes, Carlos; Freitas, Duarte deAbstract The mode of action of the lithium ion (Li+) in the treatment of manic depression or bipolar illness is still under investigation, although this inorganic drug has been in clinical use for 50 yr. Several research reports have provided evidence for Li+/Mg2+ competition in biomolecules. We carried out this study to characterize the interactions of Li+ and Mg2+ with red blood cell (RBC) membrane component...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||