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Pharmacological characterization of Solanum cernuum Vell.: 31-norcycloartanones...
Lopes, Luciane C.; Carvalho, João E.; Kakimore, Marise; Vendramini-Costa, Débora B.; Medeiros, Maria Augusta; Spindola, Humberto M.; Ávila-Román, J.Cycloeucalenone (1) and 24-oxo-31-norcycloartanone (2) obtained from Solanum cernuum Vell. were assayed to explore their pharmacologic roles. Previous studies showed that (2) has selective activity against lung tumor cell line (NCIH460) which expresses high levels of COX-2, suggesting its role in inflammatory process, and also a link between chronic inflammation and cancer-associated process. Dichloromethane cr...
Furanoditerpenes from Pterodon pubescens benth with selective in vitro anticanc...
Spindola,Humberto M.; Carvalho,João E. de; Ruiz,Ana Lúcia T. G.; Rodrigues,Rodney A. F.; Denny,Carina; Sousa,Ilza M. de Oliveira; Tamashiro,Jorge Y.Activity guided fractionation of Pterodon pubescens Benth. methylene chloride-soluble fraction afforded novel 6α-acetoxi 7β-hydroxy-vouacapan 1 and four known diterpene furans 2, 3, 4, 5. The compounds were evaluated for in vitro cytotoxic activities against human normal cells and tumour cell lines UACC-62 (melanoma), MCF-7 (breast), NCI-H460 (lung, non-small cells), OVCAR-03 (ovarian), PC-3 (prostate...
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