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Empiema Sub-Dural Causado por Salmonela. A Propósito dum Caso Clínico
João, Anabela; Godinho, Cristina; Rezende, Mário; Guedes, Margarida; Machado, AntónioInfecções intracraneanas focais constituem manifestações raras de salmonelose, podendo ocorrer como complicação de meningite, trauma ou hematoma intracraneano. Descreve-se o caso clínico de um empiema causado por Salmonela não typhy do grupo D, que complicou um hematoma sub-dural ocorrido num lactente de 8 meses, com boa evolução após terapêutica antibiótica e drenagem cirúrgica.
Gravidez não Vigiada — Que Risco Infeccioso no Recém-Nascido?
Madalena, Célia; Oliveira, Dulce; Guedes, Margarida; Machado, AntónioNo Sector de Lactentes do Serviço de Pediatria do Hospital Geral de Santo António tem-se assistido a um aumento do número de infecções congénitas diagnosticadas tardiamente. Por este motivo, os autores decidiram implementar um programa de rastreio a todos os Recém-Nascidos (RN) inetrnados com gestação não vigiada, visando avaliar a dimensão do risco infeccioso e as vantagens de instituir esse mesmo estudo a tod...
Leucemia Mielóide Crónica Juvenil: Caso Clínico
Guimarães, Paulo; Godinho, Cristina; Fonseca, Teimo; Pinto, Armando; Guedes, Margarida; Machado, AntónioA Leucemia Mielóide Crónica Juvenil é uma doença mieloproliferativa rara, ocorrendo predominantemente antes dos dois anos de idade.A apresentação clínica inclui exantema facial, adenomegalias, hepatoesplenomegalia e manifestações hemorrágicas. Hematologicamente verifica-se anemia, leucocitose (com monocitose e «desvio para a esquerda») e trombocitopenia.A sobrevida média é inferior a nove meses, sendo o óbito g...
Fluorescence in situ hybridization method using a peptide nucleic acid probe fo...
Machado, António; Almeida, Carina; Carvalho, Ana; Boyen, Filip; Haesebrouck, Freddy; Rodrigues, L. R.; Cerca, Nuno; Azevedo, N. F.Lactobacillus species constitute one of the dominant and beneficial bacteria in our body and are used in developed countries as a microbial adjuvant. Identification of these probiotic bacteria is traditionally performed by culture-based techniques. However, such methods are very time-consuming and can give inaccurate results, especially when Lactobacillus is present in mixed bacterial complex communities. Our s...
Fluorescence in situ hybridization method using peptide nucleic acid probes for...
Machado, António; Almeida, Carina; Salgueiro, D. A. L.; Henriques, Ana Filipa; Vaneechoutte, Mario; Haesebrouck, Freddy; Vieira, M. J.; Rodrigues, L. R.Background: Bacterial vaginosis (BV) is a common vaginal infection occurring in women of reproductive age. It is widely accepted that the microbial switch from normal microflora to BV is characterized by a decrease in vaginal colonization by Lactobacillus species together with an increase of Gardnerella vaginalis and other anaerobes. Our goal was to develop and optimize a novel Peptide Nucleic Acid (PNA) Fluore...
Reciprocal interference between Lactobacillus spp. and Gardnerella vaginalis on...
Castro, J.; Henriques, A.; Machado, António; Henriques, Mariana; Jefferson, Kimberly K.; Cerca, NunoBacterial vaginosis (BV) is the most common vaginal disorder in women of child-bearing age. It is widely accepted that the microbial switch from normal microflora to the flora commonly associated with BV is characterized by a decrease in vaginal colonization by specific Lactobacillus species together with an increase of G. vaginalis and other anaerobes. However, the order of events leading to the development of...
Quantitative analysis of initial adhesion of bacterial vaginosis-associated ana...
Machado, António; Salgueiro, Débora; Harwich, Michael; Jefferson, Kimberly K.; Cerca, NunoBacterial vaginosis is the leading vaginal disorder but the transition from health to this dysbiotic condition remains poorly characterized. Our goal was to quantify the ability of BV-associated anaerobes to adhere to epithelial cells in the presence of lactobacilli. Gardnerella vaginalis outcompeted Lactobacillus crispatus and Lactobacillus iners actually enhanced its adherence.
Functional analysis of virulence potential from Gardnerella vaginalis and other...
Castro, J.; Machado, António; Alves, P.; Sousa, Cármen; Cereija, Tatiana; França, Ângela; Jefferson, Kimberly K.; Cerca, NunoIn the past half century, bacterial vaginosis (BV) has been a controversial topic in medical microbiology, and despite the wealth of information on this topic, the etiological agent has not yet been definitively identified [1]. The first advances on BV pointed Gardnerella vaginalis as the infectious causative agent of BV [2] but soon after it was found that G. vaginalis was also present in healthy women [3]. Ad...
Quantitative analysis of initial adhesion of bacterial vaginosis anaerobes in M...
Machado, António; Salgueiro, Débora; Harwich, Michael; Jefferson, Kimberly K.; Cerca, NunoBacterial vaginosis (BV) is the most common vaginal disorder in women of reproductive age [1]. Despite decades of research, the etiology of BV still remains elusive. It is well established that adhesion to host cells or tissues is a necessary early step in the establishment of infection [2]. Since it is often considered a polymicrobial condition, it has been proposed that some bacteria have a preponderant role...
In silico vs in vitro analysis of primer specificity for the detection of Gardn...
Henriques, Ana Filipa; Cereija, Tatiana; Machado, António; Cerca, NunoBacterial vaginosis (BV) is a common pathology of women in reproductive age that can lead to serious health complications, and is associated with shifts in the normal microflora from predominance of Lactobacillus spp. to a proliferation of other anaerobes such as G. vaginalis and A vaginae, which can be detected by PCR. The optimal PCR pathogen detection assay relies mainly on the specificity and sensitivity of...
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